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Titolo:
Electrophysiological evidence of persisting unilateral auditory cortex dysfunction in the late outcome of Landau and Kleffner syndrome
Autore:
Wioland, N; Rudolf, G; Metz-Lutz, MN;
Indirizzi:
Hop Univ Strasbourg, Neurol Clin, Serv Explorat Fonctionnelles Syst Nerveux, F-67091 Strasbourg, France Hop Univ Strasbourg Strasbourg France F-67091 F-67091 Strasbourg, France INSERM, U398, Strasbourg, France INSERM Strasbourg FranceINSERM, U398, Strasbourg, France
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 2, volume: 112, anno: 2001,
pagine: 319 - 323
SICI:
1388-2457(200102)112:2<319:EEOPUA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED-POTENTIALS; DIPOLE MODEL; N1 WAVE; SCALP; CHILDREN; SLEEP; AGE; AEP;
Keywords:
auditory evoked potential; N1; development; Landau and Kleffner syndrome; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Wioland, N Hop Univ Strasbourg, Neurol Clin, Serv Explorat Fonctionnelles Syst Nerveux, F-67091 Strasbourg, France Hop Univ Strasbourg Strasbourg France F-67091 asbourg, France
Citazione:
N. Wioland et al., "Electrophysiological evidence of persisting unilateral auditory cortex dysfunction in the late outcome of Landau and Kleffner syndrome", CLIN NEU, 112(2), 2001, pp. 319-323

Abstract

Objectives: In the late outcome of Landau and Kleffner syndrome (LKS), a childhood-acquired epileptic aphasia, most patients show after complete recovery of epilepsy a permanent one-ear extinction on dichotic listening restscontralateral to the temporal cortex previously affected by the epileptic focus. The pathophysiological significance of this dichotic extinction is not yet understood. It may be a consequence of a permanent dysfunction in the auditory system due to epileptic activity during the maturing period of the auditory system. Evoked potentials were used to check this hypothesis and to localize the level of the dysfunction along the auditory pathways. Methods: Early, middle latency and late auditory evoked potentials were recorded in 5 right-handed children having recovered from LKS. They were compared with those of 5 control children paired for age and gender. Results: In all 5 LKS patients, early and middle latency auditory evoked potentials were normal. But the amplitude of Nle (arising from associative auditory areas) was strongly reduced at temporal electrodes contralateral tothe extinguished ear, whereas latency and amplitude of Nib (related to primary auditory areas) were in the normal range. Conclusions: Unilateral voltage reduction of late auditory evoked potentials over the temporal areas previously involved by epileptic discharges suggests a permanent dysfunction in the associative auditory cortex, the behavioral expression of which is the unilateral dichotic extinction. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:04:54