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Titolo:
Equine muscular dystrophy with myotonia
Autore:
Montagna, P; Liguori, R; Monari, L; Strong, PN; Riva, R; Di Stasi, V; Gandini, G; Cipone, M;
Indirizzi:
Univ Bologna, Sch Med, Inst Clin Neurol, I-40123 Bologna, Italy Univ Bologna Bologna Italy I-40123 t Clin Neurol, I-40123 Bologna, Italy Sheffield Hallam Univ, Div Biomed Sci, Sheffield S1 1WB, S Yorkshire, England Sheffield Hallam Univ Sheffield S Yorkshire England S1 1WB shire, England Univ Bologna, Dept Vet Clin Sci, Bologna, Italy Univ Bologna Bologna Italy v Bologna, Dept Vet Clin Sci, Bologna, Italy
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 2, volume: 112, anno: 2001,
pagine: 294 - 299
SICI:
1388-2457(200102)112:2<294:EMDWM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
APAMIN RECEPTORS; MOLECULAR-BASIS; COLCHICINE; EXPANSION; MYOPATHY; MUSCLES; DISEASE; REPEAT; DOG;
Keywords:
equine; muscular dystrophy; myotonia; apamin; myotonic dystrophy; EMG in myotonia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Montagna, P Univ Bologna, Sch Med, Inst Clin Neurol, Via U Foscolo 7, I-40123 Bologna,Italy Univ Bologna Via U Foscolo 7 Bologna Italy I-40123 ogna,Italy
Citazione:
P. Montagna et al., "Equine muscular dystrophy with myotonia", CLIN NEU, 112(2), 2001, pp. 294-299

Abstract

Objectives: To describe a case of equine muscular dystrophy with myotonia. Methods: A 5-year-old horse presented with hypertrophy and delayed relaxation of the muscles of the hindlimbs from age 2 months. Testicular atrophy developed from 2 years of age. Action and percussion myotonia was associatedwith weakness in these muscles, and EMG showed diffuse myotonic dischargesand myopathic features. Biopsy of the gluteal muscle showed adipose and connective tissue infiltration, marked variation in muscle fibre size, and moth-eaten, ring and whorled fibres. Results: Injection of apamin, a peptide blocker of calcium-activated potassium channels, which inhibits myotonia in human myotonic dystrophy. was ineffective in blocking myotonic discharges. Discharges promptly abated with 2% lidocaine injection. Conclusions: Myotonia in this horse is associated with dystrophic changes similar to human myotonic dystrophy, though there are some pharmacological differences. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:41:34