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Titolo:
Motor thresholds in humans: a transcranial magnetic stimulation study comparing different pulse waveforms, current directions and stimulator types
Autore:
Kammer, T; Beck, S; Thielscher, A; Laubis-Herrmann, U; Topka, H;
Indirizzi:
Max Planck Inst Biol Cybernet, Dept Neurobiol, D-72076 Tubingen, Germany Max Planck Inst Biol Cybernet Tubingen Germany D-72076 Tubingen, Germany Univ Ulm, Dept Psychiat 3, Ulm, Germany Univ Ulm Ulm GermanyUniv Ulm, Dept Psychiat 3, Ulm, Germany Univ Tubingen, Dept Neurol, D-7400 Tubingen, Germany Univ Tubingen Tubingen Germany D-7400 t Neurol, D-7400 Tubingen, Germany
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 2, volume: 112, anno: 2001,
pagine: 250 - 258
SICI:
1388-2457(200102)112:2<250:MTIHAT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE; BRAIN-STIMULATION; COIL ORIENTATION; CORTEX; EXCITATION; EXCITABILITY; DEPRESSION; MIGRAINE;
Keywords:
human motor cortex; thresholds; current direction; pulse waveform; stimulation effectiveness; transformation factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kammer, T Max Planck Inst Biol Cybernet, Dept Neurobiol, Spemannstr 38, D-72076 Tubingen, Germany Max Planck Inst Biol Cybernet Spemannstr 38 Tubingen Germany D-72076
Citazione:
T. Kammer et al., "Motor thresholds in humans: a transcranial magnetic stimulation study comparing different pulse waveforms, current directions and stimulator types", CLIN NEU, 112(2), 2001, pp. 250-258

Abstract

Objectives: To evaluate the stimulation effectiveness of different magnetic stimulator devices with respect to pulse waveform and current direction in the motor cortex. Methods: In 8 normal subjects we determined motor thresholds of transcranial magnetic stimulation in a small hand muscle. We used focal figure-of-eight coils of 3 common stimulators (Dantec Magpro, Magstim 200 and Magstim Rapid) and systematically varied current direction (postero-anterior versus antero-posterior, perpendicular to the central sulcus) as well as pulse waveform (monophasic versus biphasic). The coil position was kept constant witha stereotactic positioning device. Results: Motor thresholds varied consistently with changing stimulus parameters, despite substantial interindividual variability. By normalizing the values with respect to the square root of the energy of the capacitors in the different stimulators, we found a homogeneous pattern of threshold variations. The normalized Magstim threshold values were consistently higher than the normalized Dantec thresholds by a factor of 1.3. For both stimulator types the monophasic pulse was more effective if the current passed the motor cortex in a postero-anterior direction rather than antero-posterior. In contrast, the biphasic pulse was weaker with the first upstroke in the postero-anterior direction. We calculated mean factors for transforming the intensity values of a particular configuration into that of another configuration by normalizing the different threshold values of each individual subject to his lowest threshold value. Conclusions: Our transformation factors allow us to compare stimulation intensities from studies using different devices and pulse forms. The effectiveness of stimulation as a function of waveform and current direction follows the same pattern as in a peripheral nerve preparation (J Physiol (Lond) 513 (1998) 571). (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 19/01/20 alle ore 08:57:41