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Titolo:
Enantioselectivity of 3-amino-2-oxazolidinone derivatives with potential psychotropic activity on cellulose tris(4-methylbenzoate) chiral selector
Autore:
Chilmonczyk, Z; Ksycinska, H; Krzywda, J; Iskra-Jopa, J;
Indirizzi:
Drug Inst, PL-00725 Warsaw, Poland Drug Inst Warsaw Poland PL-00725Drug Inst, PL-00725 Warsaw, Poland Univ Bialystok, Inst Chem, Bialystok, Poland Univ Bialystok Bialystok Poland Bialystok, Inst Chem, Bialystok, Poland Pharmaceut Res Inst, Warsaw, Poland Pharmaceut Res Inst Warsaw PolandPharmaceut Res Inst, Warsaw, Poland
Titolo Testata:
CHIRALITY
fascicolo: 3, volume: 13, anno: 2001,
pagine: 148 - 152
SICI:
0899-0042(2001)13:3<148:EO3DWP>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; LIGAND-EXCHANGE CHROMATOGRAPHY; MOLECULAR-STRUCTURE; STATIONARY PHASES; CAPACITY FACTORS; RETENTION; LIPOPHILICITY; COEFFICIENTS; SEPARATION; RESOLUTION;
Keywords:
chiral discrimination; aminooxazolidinone derivatives; psychotropic drugs; chiral stationary phases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Chilmonczyk, Z Drug Inst, Ul Chelmska 30-34, PL-00725 Warsaw, Poland Drug Inst Ul Chelmska 30-34 Warsaw Poland PL-00725 Poland
Citazione:
Z. Chilmonczyk et al., "Enantioselectivity of 3-amino-2-oxazolidinone derivatives with potential psychotropic activity on cellulose tris(4-methylbenzoate) chiral selector", CHIRALITY, 13(3), 2001, pp. 148-152

Abstract

The behavior of a series of 3-amino-2-oxazolidinone derivatives with a potential hypnotic activity on achiral (octadecylsilane) and chiral (cellulosetris(4-methylbenzoate)) stationary phases was examined. The compounds differed in the composition of a substituted aromatic ring containing differentsubstituents in different positions. It was possible to resolve all the compounds with selectivity 1.11 less than or equal to alpha less than or equal to 2.74. The enantiodifferentiating power of substituents was correlated to their electron donating ability and position in the aromatic ring. Chirality 13:148-152, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:11:08