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Titolo:
Association between antibiotic resistance and the expression of Dr adhesinamong uropathogenic Escherichia coli
Autore:
Kachroo, BB;
Indirizzi:
Univ Minnesota, Sch Med, Dept Obstet & Gynecol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 ynecol, Minneapolis, MN 55455 USA
Titolo Testata:
CHEMOTHERAPY
fascicolo: 2, volume: 47, anno: 2001,
pagine: 97 - 103
SICI:
0009-3157(200103/04)47:2<97:ABARAT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-TRACT INFECTIONS; VIRULENCE FACTORS; RECEPTOR RECOGNITION; ACUTE PYELONEPHRITIS; CONTROLLED TRIAL; AFA-I; PREGNANCY; HEMAGGLUTINATION; WOMEN; BACTERIURIA;
Keywords:
fimbriae; UTI; adhesion; antibiotic; decay-accelerating factor; mannose-resistant hemagglutination; mannose-sensitive hemagglutination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kachroo, BB GB Pant Hosp, CSIR, Dept Microbiol, New Delhi 110002, India GBPant Hosp New Delhi India 110002 New Delhi 110002, India
Citazione:
B.B. Kachroo, "Association between antibiotic resistance and the expression of Dr adhesinamong uropathogenic Escherichia coli", CHEMOTHERA, 47(2), 2001, pp. 97-103

Abstract

Background: Urinary tract infections (UTIs) are a significant health problem and Escherichia coli has been exported to be the primary pathogen in approximately 80% of cases. E. coli express structures called adhesins, fimbriae or pill that help them bind to specific tissue receptors. One such adhesin is Dr, which binds to the complement dec ay-accelerating factor (CD55) on the host cell. The purpose of the present study was to review the epidemiology and antimicrobial sensitivity spectrum of Dr adhesin-bearing E. coli isolates in women with UTI. Methods and Results: A total of 337 uropathogenic E. coli isolates were collected, and mannose-resistant hemagglutination was observed in 43%, while 12.4% expressed Dr adhesin. All 337 uropathogenic E. coli isolates were found to be resistant to penicillin, oxacillin, bactericin and cloxacillin. None of the isolates was resistant to quinolones. The resistance to sulfamethaxazole was most common (90%), followed by nalidixic acid (51%) and ampicillin (41%). interestingly, uropathogenic E. coli expressing Dr adhesin had a high incidence of ampicillin resistance (83%), and only 17% of the Dr-bearing isolates were found to be resistant to an ampicillin/sulbactum combination. Conclusion: These results indicate that UTIs may be successfully treated with ampicillin in combination with a p-lactamase inhibitor, so that selective colonization by Dr adhesin-bearing uropathogenic E. coli is prevented, which is probably promoted by treating these patients with ampicillin alone. Copyright (C) 2001 S. Karger AG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 13:13:11