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Titolo:
Signal regulation by family conspiracy
Autore:
Cant, CA; Ullrich, A;
Indirizzi:
Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany Max Planck Inst Biochem Martinsried Germany D-82152 Martinsried, Germany
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 1, volume: 58, anno: 2001,
pagine: 117 - 124
SICI:
1420-682X(200101)58:1<117:SRBFC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE-PHOSPHATASE; NATURAL-KILLER-CELLS; INTEGRIN-ASSOCIATED PROTEIN; NEURAL ADHESION MOLECULE; MHC CLASS-I; ACTIVATION MOTIF; INHIBITORY RECEPTORS; BINDING-PROTEINS; DENDRITIC CELLS; MYELOID CELLS;
Keywords:
SIRP; SHPS-1; BIT; signal transduction; CD47; KARAP; DAP-12; ITIM; ITAM; inhibitory receptor; receptor tyrosine kinase; SHP-1; SHP-2; tyrosine phosphorylation; SH2 domain; tyrosine kinase; tyrosine phosphatase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Ullrich, A Max Planck Inst Biochem, Dept Mol Biol, Klopferspitz 18A, D-82152 Martinsried, Germany Max Planck Inst Biochem Klopferspitz 18A Martinsried Germany D-82152
Citazione:
C.A. Cant e A. Ullrich, "Signal regulation by family conspiracy", CELL MOL L, 58(1), 2001, pp. 117-124

Abstract

The signal regulating proteins (SIRPs) are a family of ubiquitously expressed transmembrane glycoproteins composed of two subgroups: SIRP alpha and SIRP beta, containing more than ten members. SIRP alpha has been shown to inhibit signalling through a variety of receptors including receptor tyrosinekinases and cytokine receptors. This function involves protein tyrosine kinases and is dependent on immunoreceptor tyrosine-based inhibition motifs which recruit key protein tyrosine phosphatases to the membrane. Negative regulation by SIRP alpha may also involve its ligand, CD47, in a bi-directional signalling mechanism. The SIRP beta subtype has no cytoplasmic domain but instead associates with at least one other transmembrane protein (DAP-12,or KARAP). DAP-12 possesses immunoreceptor tyrosine-based activation motifs within its cytoplasmic domain that are thought to link SIRP beta to activating machinery. SIRP alpha and SIRP beta thus have complementary roles in signal regulation and may conspire to tune the response to a stimulus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:51:02