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Titolo:
The presynaptic cytomatrix of brain synapses
Autore:
Dresbach, T; Qualmann, B; Kessels, MM; Garner, CC; Gundelfinger, ED;
Indirizzi:
Leibniz Inst Neurobiol, Dept Neurochem & Mol Biol, D-39118 Magdeburg, Germany Leibniz Inst Neurobiol Magdeburg Germany D-39118 9118 Magdeburg, Germany Univ Alabama, Dept Neurobiol, Birmingham, AL 35294 USA Univ Alabama Birmingham AL USA 35294 Neurobiol, Birmingham, AL 35294 USA
Titolo Testata:
CELLULAR AND MOLECULAR LIFE SCIENCES
fascicolo: 1, volume: 58, anno: 2001,
pagine: 94 - 116
SICI:
1420-682X(200101)58:1<94:TPCOBS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC VESICLE ENDOCYTOSIS; CLATHRIN-MEDIATED ENDOCYTOSIS; ALDRICH-SYNDROME PROTEIN; CYCLIN-DEPENDENT KINASE-5; PHORBOL ESTER RECEPTOR; CENTRAL NERVOUS-SYSTEM; REGULATES NEUROTRANSMITTER RELEASE; ACTIN-DEPOLYMERIZING PROTEIN; CULTURED HIPPOCAMPAL-NEURONS; DOMAIN-CONTAINING PROTEIN;
Keywords:
active zone; Bassoon; CAZ; endocytosis; exocytosis; neurotransmitter release; Piccolo; synapse; synaptic vesicle cycle;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
273
Recensione:
Indirizzi per estratti:
Indirizzo: Gundelfinger, ED Leibniz Inst Neurobiol, Dept Neurochem & Mol Biol, Brenneckestr 6, D-39118Magdeburg, Germany Leibniz Inst Neurobiol Brenneckestr 6 Magdeburg Germany D-39118
Citazione:
T. Dresbach et al., "The presynaptic cytomatrix of brain synapses", CELL MOL L, 58(1), 2001, pp. 94-116

Abstract

Synapses are principal sites for communication between neurons via chemical messengers called neurotransmitters. Neurotransmitters are released from presynaptic nerve terminals at the active zone, a restricted area of the cell membrane situated exactly opposite to the postsynaptic neurotransmitter reception apparatus. At the active zone neurotransmitter-containing synaptic vesicles (SVs) dock, fuse, release their content and are recycled in a strictly regulated manner. The cytoskeletal matrix at the active zone (CAZ) is thought to play an essential role in the organization of this SV cycle. Several multi-domain cytoskeleton-associated proteins, including RIM, Bassoon, Piccolo/Aczonin and Munc-13, have been identified, which are specifically localized at the active zone and thus are putative molecular components of the CAZ. This review will summarize our present knowledge about the structure and function of these CAZ-specific proteins. Moreover, we will review our present view of how the exocytotic and endocytic machineries at the site of neurotransmitter release are linked to and organized by the presynaptic cytoskeleton. Finally, we will summarize recent progress that has been made in understanding how active zones are assembled during nervous system development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:50:36