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Titolo:
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation
Autore:
Loeb, DM; Evron, E; Patel, CB; Sharma, PM; Niranjan, B; Buluwela, L; Weitzman, SA; Korz, D; Sukumar, S;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA Johns Hopkins Univ Baltimore MD USA 21231 Oncol, Baltimore, MD 21231 USA Univ Calif San Diego, Dept Med, San Diego, CA 92161 USA Univ Calif San Diego San Diego CA USA 92161 Med, San Diego, CA 92161 USA Northwestern Univ, Sch Med, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 iv, Sch Med, Chicago, IL 60611 USA Imperial Coll Sch Med, Div Med, London W12 0NN, England Imperial Coll Sch Med London England W12 0NN ed, London W12 0NN, England
Titolo Testata:
CANCER RESEARCH
fascicolo: 3, volume: 61, anno: 2001,
pagine: 921 - 925
SICI:
0008-5472(20010201)61:3<921:WTSG(I>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTIONAL REPRESSOR; CPG ISLANDS; CANCER; CELLS; HYPERMETHYLATION; CARCINOMAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Sukumar, S Johns Hopkins Oncol Ctr, BBCRB Room 410,1650 Orleans St, Baltimore, MD 21231 USA Johns Hopkins Oncol Ctr BBCRB Room 410,1650 Orleans St Baltimore MD USA 21231
Citazione:
D.M. Loeb et al., "Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation", CANCER RES, 61(3), 2001, pp. 921-925

Abstract

We analyzed Wilms' tumor suppressor 1 (WT1) expression and its regulation by promoter methylation in a panel of normal breast epithelial samples and primary carcinomas. Contrary to previous reports, WT1 protein was strongly expressed in primary carcinomas (27 of 31 tumors) but not in normal breast epithelium (1 of 20 samples). Additionally, the WT1 promoter was methylatedin 6 of 19 (32%) primary tumors, which nevertheless expressed WT1. The promoter is not methylated in normal epithelium. Thus, although tumor-specificmethylation of WT1 is established in primary breast cancer at a low frequency, other transcriptional regulatory mechanisms appear to supercede its effects in these tumors. Our results demonstrate expression of WT1 in mammaryneoplasia, and that WT1 may not have a tumor suppressor role in breast cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:40:36