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Titolo:
Multiple organ mucosa-associated lymphoid tissue lymphomas often involve the intestine
Autore:
Yoshino, T; Ichimura, K; Mannami, T; Takase, S; Ohara, N; Okada, H; Akagi, T;
Indirizzi:
Okayama Univ, Sch Med, Dept Pathol, Okayama 7008558, Japan Okayama Univ Okayama Japan 7008558 , Dept Pathol, Okayama 7008558, Japan
Titolo Testata:
CANCER
fascicolo: 2, volume: 91, anno: 2001,
pagine: 346 - 353
SICI:
0008-543X(20010115)91:2<346:MOMLTL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON CLONAL ORIGIN; LOW-GRADE; B-CELL; GASTRIC LYMPHOMA; MALT LYMPHOMA; NEOPLASMS; LESIONS; STOMACH; LUNG;
Keywords:
mucosa-associated lymphoid tissue (MALT) lymphoma; multiorgan; large intestine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshino, T Okayama Univ, Sch Med, Dept Pathol, 2-5-1 Shikata Cho, Okayama 7008558, Japan Okayama Univ 2-5-1 Shikata Cho Okayama Japan 7008558 58, Japan
Citazione:
T. Yoshino et al., "Multiple organ mucosa-associated lymphoid tissue lymphomas often involve the intestine", CANCER, 91(2), 2001, pp. 346-353

Abstract

BACKGROUND. Low grade mucose-associated lymphoid tissue (MALT) lymphomas usually are confined to single extranodal organs. Although some case reportshave been published, clinicopathologic characteristics of multiorgan MALT lymphomas remain unclear. METHODS, The authors evaluated 7 MALT lymphoma cases involving multiorgansin the past 7 years. In this period, they experienced 304 cases of MALT lymphomas. They analyzed the clinicopathologic features of these cases, including examination of clonal comparison among the lesions. RESULTS. The patients, 4 females and 3 males, were aged 55-68 years old (average, 60.1 years). Four cases showed multiple organ involvement at the initial diagnosis or after a short period. In the other three cases, primary foci were the stomach, thyroid gland, and ocular adnexa; after a rather long period (3 years or more), distant metastases were found. Although intestinal primary lymphomas are rather rare, six of the seven cases showed large intestinal involvement. Lymph node involvement was proven in only three cases. The patients were rather resistant to the various therapeutic approaches. Although six patients are alive, five are with disease. DNA analyses revealed that in five of the cases evaluated, identical clones were detected among the different affected organs. CONCLUSIONS. Multiorgan MALT lymphomas are rather rare. Most cases probably derived from a single clone, and lymphoma cells may selectively move among MALTs via a homing system with preferential involvement of the colon. Because multiorgan MALT lymphomas rarely achieve complete remission by treatment with combination chemotherapy or irradiation, MALT lymphomatous lesions should be checked carefully, especially in the large intestine. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 09:53:52