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Titolo:
Sibling risks in cancer: clues to recessive or X-linked genes?
Autore:
Hemminki, K; Vaittinen, P; Dong, C; Easton, D;
Indirizzi:
Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 Biosci, S-14157 Huddinge, Sweden Strangeways Res Labs, CRC, Genet Epidemiol Unit, Cambridge CB1 8RN, England Strangeways Res Labs Cambridge England CB1 8RN ambridge CB1 8RN, England
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 3, volume: 84, anno: 2001,
pagine: 388 - 391
SICI:
0007-0920(20010202)84:3<388:SRICCT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-CANCER; BREAST-CANCER; FAMILY HISTORY; OVARIAN-CANCER; POPULATION; RELATIVES; BRCA1; METAANALYSIS; CHROMOSOME; MORTALITY;
Keywords:
familial cancer; liability; heredity; cancer modelling; genetic epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Hemminki, K Karolinska Inst, Novum, Dept Biosci, S-14157 Huddinge, Sweden Karolinska Inst Huddinge Sweden S-14157 157 Huddinge, Sweden
Citazione:
K. Hemminki et al., "Sibling risks in cancer: clues to recessive or X-linked genes?", BR J CANC, 84(3), 2001, pp. 388-391

Abstract

A systematic analysis of cancer risks to offspring and to siblings of cancer cases was carried out based on the nationwide Swedish Family-Cancer Database. For ail 13 cancer sites examined, risks to both offspring and siblings of cases of cancer at the same site were significantly elevated. The relative risk to siblings was approximately 2 fold more than the offspring riskfar cancers of the prostate, testis, kidney and bladder, suggesting that recessive or X-linked susceptibility genes may be important for these cancers. Risks to siblings of cases where a parent was also affected were increased >20 fold over population rates for colorectal, ovarian. prostate and renal cancer, and for leukaemia, consistent with the effects of rare high-risksusceptibility alleles. (C) 2001 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:12:29