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Titolo:
Increased anxiety behavior in OLETF rats without cholecystokinin-A receptor
Autore:
Yamamoto, Y; Akiyoshi, J; Kiyota, A; Katsuragi, S; Tsutsumi, T; Isogawa, K; Nagayama, H;
Indirizzi:
Oita Med Univ, Dept Neuropsychiat, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 Dept Neuropsychiat, Oita 8795593, Japan
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 53, anno: 2000,
pagine: 789 - 792
SICI:
0361-9230(200012)53:6<789:IABIOR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED ZERO-MAZE; PANIC DISORDER; B RECEPTOR; CALCIUM MOBILIZATION; EXPLORATORY-BEHAVIOR; CCKA RECEPTORS; ANIMAL-MODELS; PLUS-MAZE; T-CELLS; ANTAGONISTS;
Keywords:
anxiety; black and white test; cholecystokinin (CCK) receptors; elevated plus-maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Akiyoshi, J Oita Med Univ, Dept Neuropsychiat, Oita 8795593, Japan Oita Med Univ Oita Japan 8795593 ychiat, Oita 8795593, Japan
Citazione:
Y. Yamamoto et al., "Increased anxiety behavior in OLETF rats without cholecystokinin-A receptor", BRAIN RES B, 53(6), 2000, pp. 789-792

Abstract

Cholecystokinin (CCK) may have a role in the mediation of human panic disorder and anxiogenic (anxiolytic)-like activity in an animal model of anxiety, Otsuka Long Evans Tokushima Fatty (OLETF) rats lacked CCK A receptors (CCKAR) because of a genetic abnormality. In order to elucidate the involvement of CCKAR in the regulation of anxiety, we investigated the exploratory behavior on elevated plus-maze test, the black and white box test, and open field test with OLETF rats in comparison with normal [Long-Evans Tokushima Otsuka (LETO)I rats, And OLETF rats increased the number of stretched attend postures and decreased open arm entry and the % time of open arm in an elevated plus-maze test, Time spent in the white box decreased significantly in OLETF rats than LETO rats, The total line crossing decreased significantly in OLETF rats compared to LETO rats, The missing CCKAR had a significantanxiogenic-like effect. These data support the involvement of the CCKAR inthe neurobiological mechanism of anxiety, (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:31:15