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Titolo:
Long-lasting effects of feline amygdala kindling on monoamines, seizures and sleep
Autore:
Shouse, MN; Staba, RJ; Saquib, SF; Farber, PR;
Indirizzi:
Greater Los Angeles Hlth Care Syst 151A3, Dept Vet Affairs, Sepulveda, CA 91343 USA Greater Los Angeles Hlth Care Syst 151A3 Sepulveda CA USA 91343 91343 USA Univ Calif Los Angeles, Ctr Hlth Sci, Dept Neurobiol, Los Angeles, CA 90063 USA Univ Calif Los Angeles Los Angeles CA USA 90063 Los Angeles, CA 90063 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 892, anno: 2001,
pagine: 147 - 165
SICI:
0006-8993(20010216)892:1<147:LEOFAK>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NUCLEUS; RAT LOCUS-COERULEUS; FREELY MOVING RATS; EXTRACELLULAR SEROTONIN CONCENTRATION; EPILEPSY-PRONE RATS; PARADOXICAL SLEEP; BEHAVIORAL STATE; NOREPINEPHRINE DEPLETION; NEUROTRANSMITTER RELEASE; NORADRENALINE RELEASE;
Keywords:
monoamine; developmental amygdala kindling; sleep; microdialysis; cat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
88
Recensione:
Indirizzi per estratti:
Indirizzo: Shouse, MN 2242 S Bentley Ave 4, Los Angeles, CA 90064 USA 2242 S BentleyAve 4 Los Angeles CA USA 90064 es, CA 90064 USA
Citazione:
M.N. Shouse et al., "Long-lasting effects of feline amygdala kindling on monoamines, seizures and sleep", BRAIN RES, 892(1), 2001, pp. 147-165

Abstract

This report describes the relationship between monoamines, sleep and seizures before and 1-month after amygdala kindling in young cats (<1 year old; n=8; six female and two male). Concentrations (fmoles of norepinephrine or NE, dopamine or DA and serotonin or 5-HT) were quantified in consecutive, 5-min microdialysis samples (2 <mu>l/min infusion rate) from amygdala and locus ceruleus complex (LC) during four, 6-8-h polygraphic recordings before (n=2) and 1 month post-kindling (n=2); 5-min recording epochs were temporally adjusted to correspond to dialysate samples and differentiated accordingto dominant sleep or waking state (lasting greater than or equal to 80% of5-min epoch) and degree of spontaneous seizure activity (number and duration of focal versus generalized spikes and spike trains and behavioral seizure correlates). Post-kindling records in each cat were divided into two groups (n=1 record each) based on higher or lower spontaneous EEG and behavioral seizure activity and compared to pre-kindling records. We found: (1) before and after kindling, NE and 5-HT but not DA concentrations were significantly lower in sleep than waking at both sites; (2) after kindling, each cat showed cyclic patterns, as follows: (a) higher NE, 5-HT and DA concentrations accompanied increased seizure activity with delayed sleep onset latency and increased sleep fragmentation (reduced sleep state percentages, number of epochs and/or epoch duration) in one recording versus (b) lower monoaminergic concentrations accompanied reduced seizure activity, rapid sleep onset and reduced sleep disruption in the other recording. The alternating, post-kindling pattern suggested 'rebound' effects which could explain some controversies in the literature about chronic effects of kindling on monoamines and sleep-waking state patterns. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 03/04/20 alle ore 14:11:58