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Titolo:
Long-term effects of a high-dose methamphetamine regimen on subsequent methamphetamine-induced dopamine release in vivo
Autore:
Sabol, KE; Roach, JT; Broom, SL; Ferreira, C; Preau, MM;
Indirizzi:
Univ Mississippi, Dept Psychol, University, MS 38677 USA Univ MississippiUniversity MS USA 38677 sychol, University, MS 38677 USA Univ Mississippi, Dept Pharmacol, University, MS 38677 USA Univ Mississippi University MS USA 38677 rmacol, University, MS 38677 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 892, anno: 2001,
pagine: 122 - 129
SICI:
0006-8993(20010216)892:1<122:LEOAHM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICRODIALYSIS PROBE INSERTION; POSITRON-EMISSION-TOMOGRAPHY; STRIATAL DOPAMINE; RAT-BRAIN; CORE TEMPERATURE; EVOKED OVERFLOW; C-11 WIN-35,428; NEUROTOXICITY; AMPHETAMINE; DECLINES;
Keywords:
methamphetamine; high-dose regimen; in vivo dopamine release; neurotoxicity; temperature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Sabol, KE Univ Mississippi, Dept Psychol, 205 Peabody Bldg, University, MS38677 USA Univ Mississippi 205 Peabody Bldg University MS USA 38677 77 USA
Citazione:
K.E. Sabol et al., "Long-term effects of a high-dose methamphetamine regimen on subsequent methamphetamine-induced dopamine release in vivo", BRAIN RES, 892(1), 2001, pp. 122-129

Abstract

Rats were treated with a high-dose methamphetamine (METH) regimen (40 mg/kg/injection, four times at 2-h intervals) or a saline regimen (four injections at 2-h intervals). Temperature related measures taken during the high-dose METH treatment were maximum core temperature and minimum chamber temperature. Fourteen rats (METH N=7; Saline N=7) were implanted with in-vivo dialysis probes 4-7 weeks post-regimen (average=6 weeks). The next day, they received a challenge dose of METH (4.0 mg/kg) and dopamine release was measured. Results showed a significant decrease in challenge-induced dopamine release in rats previously treated with the high-dose METH regimen. These findings demonstrate a functional deficit in the dopamine system 6 weeks afterhigh-dose METH treatment. Temperature-related measures taken during the high-dose regimen were not correlated with METH-induced dopamine release 6 weeks later. An additional group of rats were sacrificed 6 weeks after the high-dose regimen (METH N=12; Saline N=10), and their brains was analyzed fordopamine and serotonin concentrations. Tissue concentrations of dopamine were significantly depleted in striatum and nucleus accumbens/olfactory tubercle, but not septum, hypothalamus, or ventral mid-brain 6 weeks after the high-dose regimen. Tissue concentrations of serotonin were also significantly depleted in striatum, nucleus accumbens/olfactory tubercle, hippocampus,somatosensory cortex, but not septum, hypothalamus or ventral mid-brain. Significant correlations between the temperature-related measures and post-mortem neurotransmitter tissue concentrations were region and transmitter dependent. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:21:01