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Titolo:
The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system
Autore:
Gao, XM; Dluzen, DE;
Indirizzi:
NE Ohio Univ, Coll Med, Dept Anat, Rootstown, OH 44272 USA NE Ohio Univ Rootstown OH USA 44272 d, Dept Anat, Rootstown, OH 44272 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 892, anno: 2001,
pagine: 63 - 69
SICI:
0006-8993(20010216)892:1<63:TEOTUM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MPTP-INDUCED NEUROTOXICITY; CASTRATED MALE-RATS; MONOAMINE-OXIDASE; ESTROGEN-TREATMENT; STRIATAL DOPAMINE; SEXUAL DIFFERENCES; C57/B1 MICE; BRAIN; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; AMPHETAMINE;
Keywords:
corpus striatum; Parkinson's disease; dopamine; estrogen; gender differences;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Dluzen, DE NE Ohio Univ, Coll Med, Dept Anat, 4209 State Route 44,POB 95, Rootstown, OH 44272 USA NE Ohio Univ 4209 State Route 44,POB 95 Rootstown OH USA 44272
Citazione:
X.M. Gao e D.E. Dluzen, "The effect of testosterone upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system", BRAIN RES, 892(1), 2001, pp. 63-69

Abstract

The gonadal steroid hormone estrogen (E) can function as a neuroprotectantof nigrostriatal dopaminergic (NSDA) neurotoxicity, however, there exists very limited information on the role of testosterone (T) in this capacity. In the present report, the effects of T on methamphetamine (MA) induced neurotoxicity of the NSDA system were examined in gonadectomized female and male CD-1 mice. In Experiment I, striatal dopamine (DA) concentrations and output from T-treated ovariectomized mice were not significantly different from that of non-T-treated mice following MA. These results suggest that T isnot functioning as a modulator of MA-induced NSDA neurotoxicity in ovariectomized CD-1 mice. In Experiment 2, there were no significant differences in DA concentrations or output among T-treated, non-T-treated as well as E-treated orchidectomized mice following MA. The results of Experiment 2 indicate that the neuroprotective effect of E reported within ovariectomized mice is not seen in male mice. Nor does T appear to function as a modulator ofMA neurotoxicity in male mice. These effects of T and E upon the MA induced neurotoxicity of the NSDA system have important implications for the gender differences which are observed in animal models of NSDA neurotoxicity and in Parkinson's disease. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 06:30:16