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Titolo:
SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity
Autore:
Muralikrishnan, D; Ebadi, M;
Indirizzi:
Univ N Dakota, Sch Med & Hlth Sci, Dept Pharmacol Physiol & Therapeut, Grand Forks, ND 58203 USA Univ N Dakota Grand Forks ND USA 58203 erapeut, Grand Forks, ND 58203 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 892, anno: 2001,
pagine: 241 - 247
SICI:
0006-8993(20010223)892:2<241:SADRAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-B; PARKINSONS-DISEASE; LIPID-PEROXIDATION; NADH DEHYDROGENASE; SUPEROXIDE ANION; MOUSE-BRAIN; L-DEPRENYL; SKF 38393; MPTP; MONKEYS;
Keywords:
Parkinson's disease; oxidative stress; neurodegeneration; 1-methyl-4-phenyl-1,2,3,6-tetraydropyridine; MPTP; selegiline; SKF-38393; dopamine receptor agonist; neuroprotection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Ebadi, M Univ N Dakota, Sch Med & Hlth Sci, Dept Pharmacol Physiol & Therapeut, 501N Columbia Rd, Grand Forks, ND 58203 USA Univ N Dakota 501 N Columbia Rd Grand Forks ND USA 58203 8203 USA
Citazione:
D. Muralikrishnan e M. Ebadi, "SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity", BRAIN RES, 892(2), 2001, pp. 241-247

Abstract

Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Several factors such as inhibition of the mitochondrial respiration, generation of hydroxyl radicals and reduced free radical defense mechanisms causing oxidative stress, have been postulated to contribute to the degeneration of dopaminergic neurons. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated animals is a useful experimental model of PD, exhibiting most of the clinical features, as well as the main biochemical and pathologic symptoms of the disease. In the present study, we have examined a dopaminergic (D-1) receptor agonist, SKF-38393 HCl (SKF) for its possible neuroprotective action against MPTP induced insults ondopaminergic neurons. MPTP is converted by monoamine oxidase-B (MAO-B) to its neurotoxic metabolite 1-methyl-4-phenyl-pyridinium (MPP+). which is then taken up into the dopaminergic neurons. SKF-38393 had no effects tither on total or monoamine oxidase B in the striatum. SKF-38393 blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine. Furthermore. it enhanced the activity of superoxide dismutase and hence mimicked the action of selegiline. The results of these studies are interpreted to suggest that SKF-38393 may prove a valuable drug in the treatment of Parkinsons disease. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:05:38