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Titolo:
Relaxation induced by omeprazole does not change in diabetic rabbit corpuscavernosum
Autore:
Ayan, S; Sarioglu, Y; Yildirim, S; Gokce, G; Bagcivan, I;
Indirizzi:
Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ, Sch Med, Dept Urol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 Dept Urol, TR-58140 Sivas, Turkey
Titolo Testata:
BJU INTERNATIONAL
fascicolo: 3, volume: 87, anno: 2001,
pagine: 265 - 268
SICI:
1464-4096(200102)87:3<265:RIBODN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATPASE;
Keywords:
corpus cavernosum; diabetes mellitus; erectile dysfunction; omeprazole;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Sarioglu, Y Cumhuriyet Univ, Sch Med, Dept Pharmacol, TR-58140 Sivas, Turkey Cumhuriyet Univ Sivas Turkey TR-58140 TR-58140 Sivas, Turkey
Citazione:
S. Ayan et al., "Relaxation induced by omeprazole does not change in diabetic rabbit corpuscavernosum", BJU INT, 87(3), 2001, pp. 265-268

Abstract

Objective To investigate the changes in relaxation responses to omeprazolein corpus cavernosal strips from rabbits with diabetes induced by alloxan. Materials and methods Diabetes was induced in 10 New Zealand white rabbits. After 8 weeks, the reactivity to electrical-field stimulation, carbachol and omeprazole of corporal strips from the penises of the diabetic animals and from 10 untreated controls was assessed in organ chambers. Results In the diabetic group, the relaxation responses of corpus cavernosal strips to omeprazole were comparable with those of the control group, whereas the relaxation responses to electrical field stimulation and carbachol were impaired. Conclusion The relaxant effect of omeprazole in corpus cavernosum was not affected by diabetes, in which neurogenic and endothelium-mediated relaxations were impaired.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:18:43