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Titolo:
Acrolein inhibits respiration in isolated brain mitochondria
Autore:
Picklo, MJ; Montine, TJ;
Indirizzi:
Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 pt Pathol, Nashville, TN 37232 USA
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
fascicolo: 2, volume: 1535, anno: 2001,
pagine: 145 - 152
SICI:
0925-4439(20010214)1535:2<145:AIRIIB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-C RELEASE; ALZHEIMERS-DISEASE; LIPID-PEROXIDATION; PERMEABILITY TRANSITION; LIQUID-CHROMATOGRAPHY; IMMUNOHISTOCHEMICAL DETECTION; OXIDATIVE STRESS; APOE GENOTYPE; ALDEHYDES; NEURODEGENERATION;
Keywords:
acrolein; lipid peroxidation; mitochondria; neurodegeneration; Alzheimer's disease; respiration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Picklo, MJ Vanderbilt Univ, Med Ctr, Dept Pathol, Nashville, TN 37232 USA Vanderbilt Univ Nashville TN USA 37232 Nashville, TN 37232 USA
Citazione:
M.J. Picklo e T.J. Montine, "Acrolein inhibits respiration in isolated brain mitochondria", BBA-MOL BAS, 1535(2), 2001, pp. 145-152

Abstract

Lipid peroxidation is elevated in diseased regions of brain in several neurodegenerative diseases. Acrolein (2-propenal) is a major cytotoxic productof lipid peroxidation and its adduction to neuronal proteins has been demonstrated in diseased brain regions from patients with Alzheimer's disease. Mitochondrial abnormalities are implicated in several neurodegenerative disorders, and mitochondria are targets of alkenal adduction in vivo. We examined the effects of acrolein upon multiple endpoints associated with the mitochondrial involvement in neurodegenerative disease. Acrolein inhibited state 3 respiration with an IC50 of approx. 0.4 mu mol/mg protein; however, there was no reduction in activity of complexes I-V. This inhibition was prevented by glutathione and N-acetylcysteine. Acrolein did not alter mitochondrial calcium transporter activity or induce cytochrome c release. These studies indicate that acrolein is a potent inhibitor of brain mitochondrial respiration. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:11:35