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Titolo:
Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes
Autore:
Furukawa, K; Takamiya, K; Okada, M; Inoue, M; Fukumuto, S; Furukawa, K;
Indirizzi:
Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, Nagoya, Aichi 4660065, Japan Nagoya Univ Nagoya Aichi Japan 4660065 a Ku, Nagoya, Aichi 4660065, Japan Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA Johns Hopkins Univ Baltimore MD USA 21205 urosci, Baltimore, MD 21205 USA Nagasaki Univ, Sch Med, Dept Pediat, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 h Med, Dept Pediat, Nagasaki 852, Japan Nagasaki Univ, Sch Med, Dept Pediat Dent, Nagasaki 852, Japan Nagasaki Univ Nagasaki Japan 852 , Dept Pediat Dent, Nagasaki 852, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
fascicolo: 1-2, volume: 1525, anno: 2001,
pagine: 1 - 12
SICI:
0304-4165(20010216)1525:1-2<1:NFOCCE>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASPARAGINE-LINKED OLIGOSACCHARIDES; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; HEPARAN-SULFATE 2-SULFOTRANSFERASE; SELECTIN LIGANDS; NERVOUS-SYSTEM; TARGETED DISRUPTION; CD22-DEFICIENT MICE; DEPENDENT SYNTHESIS; MOLECULAR-CLONING; MAST-CELLS;
Keywords:
carbohydrate; complex carbohydrate; gene knock-out; glycosyltransferase; sulfotransferase; glycoconjugate;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, K Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, 65 Tsurumai, Nagoya, Aichi4660065, Japan Nagoya Univ 65 Tsurumai Nagoya Aichi Japan 4660065 0065, Japan
Citazione:
K. Furukawa et al., "Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes", BBA-GEN SUB, 1525(1-2), 2001, pp. 1-12

Abstract

Complex carbohydrates consist of carbohydrate moieties and protein or lipid portions, resulting in the formation of glycoproteins, proteoglycans or glycosphingolipids. The polymorphic carbohydrate structures are believed to contain profound biological implications which are important in cell-cell or cell-extracellular matrix interactions. A number of studies to delineate the roles of carbohydrates have been performed, and demonstrated definite changes in their profiles, cellular phenotypic changes or, sometimes, morphological and functional changes in tissues after modification of their structures. Recent successes in the isolation of glycosyltransferase genes and their modification enzyme genes has enabled clearer demonstrations of the roles of complex carbohydrates. In particular, genetic modification of glycosyltransferase genes in mice can elucidate the biological significances of their products in vivo. Here, we summarize recent advances in the understanding of the roles of complex carbohydrates provided from studies of gene knock-out mice of glycosyltransferase and modification enzyme genes focusing on novel functions which had not been expected. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 20:36:30