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Titolo:
Exploiting the apoptotic process for management of HIV: Are we there yet ?
Autore:
Yang, Y; Ashwell, JD;
Indirizzi:
NCI, Lab Immune Cell Biol, Div Basic Sci, NIH, Bethesda, MD 20892 USA NCIBethesda MD USA 20892 iol, Div Basic Sci, NIH, Bethesda, MD 20892 USA
Titolo Testata:
APOPTOSIS
fascicolo: 1-2, volume: 6, anno: 2001,
pagine: 139 - 146
SICI:
1360-8185(200102)6:1-2<139:ETAPFM>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TUMOR-NECROSIS-FACTOR; CD4(+) T-CELLS; BLOOD MONONUCLEAR-CELLS; FAS LIGAND EXPRESSION; RETINOIC ACID INHIBITION; CROSS-LINKING; FACTOR-ALPHA; UP-REGULATION; INFECTED INDIVIDUALS;
Keywords:
apoptosis; HIV; T cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
95
Recensione:
Indirizzi per estratti:
Indirizzo: Ashwell, JD NCI, Lab Immune Cell Biol, Div Basic Sci, NIH, Room 1B-40,Bldg10,9000 Rockville Pike, Bethesda, MD 20892 USA NCI Room 1B-40,Bldg 10,9000Rockville Pike Bethesda MD USA 20892
Citazione:
Y. Yang e J.D. Ashwell, "Exploiting the apoptotic process for management of HIV: Are we there yet ?", APOPTOSIS, 6(1-2), 2001, pp. 139-146

Abstract

CD4(+) T cells die in individuals infected with HIV, either as a result ofdirect HIV infection or as uninfected "innocent bystanders". Possible mechanisms for bystander killing include generation of viral products such as Tat or gp120 and expression of death receptor ligands, such as FasL, that engage functional death receptors on uninfected cells. This review covers thesometimes conflicting in vitro and ex vivo studies that address these possible mechanisms of HIV-associated cell death. It is an intriguing possibility that manipulation of cell death processes, to decrease bystander death or increase death of infected cells, in patients infected with HIV might provide a useful adjunct to antiretroviral therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:58:42