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Titolo:
Will imaging of apoptosis play a role in clinical care? A tale of mice andmen
Autore:
Blankenberg, FG; Strauss, HW;
Indirizzi:
Stanford Univ, Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Univ, Sch Med, Stanford, CA 94305 USA
Titolo Testata:
APOPTOSIS
fascicolo: 1-2, volume: 6, anno: 2001,
pagine: 117 - 123
SICI:
1360-8185(200102)6:1-2<117:WIOAPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIOLABELED ANNEXIN-V; IN-VIVO DETECTION; LUNG-TRANSPLANT REJECTION; CEREBRAL HYPOXIA-ISCHEMIA; PROGRAMMED CELL-DEATH; ALLOGRAFT-REJECTION; CASPASE INHIBITOR; MYOCARDIAL-INFARCTION; NMR-SPECTROSCOPY; TISSUE-INJURY;
Keywords:
annexin; imaging; radionuclide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Strauss, HW Stanford Univ, Sch Med, 300 Pasteur Dr Room H0101, Stanford, CA 94305 USA Stanford Univ 300 Pasteur Dr Room H0101 Stanford CA USA 94305
Citazione:
F.G. Blankenberg e H.W. Strauss, "Will imaging of apoptosis play a role in clinical care? A tale of mice andmen", APOPTOSIS, 6(1-2), 2001, pp. 117-123

Abstract

Programmed cell death (apoptosis) plays a role in the pathophysiology of many diseases and in the outcome of treatment. Apoptosis is the likely mechanism behind the cytoreductive effects of standard chemotherapeutic and radiation treatments, rejection of organ transplants, cellular damage in collagen vascular disorders, and delayed cell death due to hypoxic-ischemic injury in myocardial infarction and neonatal hypoxic ischemic injury. Observations about the role of apoptosis have fueled the development of novel agents and treatment strategies specifically aimed at inducing or inhibiting apoptosis. Despite these research developments there are no clinical entities where specific measures of apoptosis are used in either diagnosis or patient management. Part of the difficulty in bridging the gap between the basic scienceunderstanding of apoptosis and the clinical application of this information is the lack of a sensitive marker to monitor programmed cell death in association with disease progression or regression. Technetium-99m labeled annexin V localizes at sites of apoptosis in-vivo, due to its nanomolar affinity for membrane bound phosphatidylserine. Radiolabeled annexin V imaging permits identification of the site and extent of apoptosis in experimental animals. Annexin V has been successfully used in animal models to image organtransplant rejection, characterize successful therapy of tumors, pinpoint acute myocardial infarction, and identify hypoxic ischemic brain injury of the newborn and adult. Early studies in human subjects suggest that Tc-99m annexin imaging will be also be useful to identify rejection in transplant recipients, localize acute myocardial infarction, and characterize the effectiveness of a single treatment in patients with tumors. This review describes the imaging approaches to detect and monitor apoptosis in-vivo that are presently in early clinical trials. The preliminary data are extrapolated to identify conditions where apoptosis imaging may be valuable in clinical decision making. These conditions include: transplant rejection; hypoxic/ischemic injury of heart and brain; and determining the efficacy of therapy in cancer, heart failure and osteoporosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 09:23:40