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Titolo:
Apoptosis in AIDS
Autore:
Roshal, M; Zhu, Y; Planelles, V;
Indirizzi:
Univ Rochester, Ctr Canc, Dept Med, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 , Dept Med, Rochester, NY 14642 USA Univ Rochester, Ctr Canc, Dept Microbiol & Immunol, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 & Immunol, Rochester, NY 14642 USA
Titolo Testata:
APOPTOSIS
fascicolo: 1-2, volume: 6, anno: 2001,
pagine: 103 - 116
SICI:
1360-8185(200102)6:1-2<103:AIA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TYPE-1 TAT PROTEIN; NF-KAPPA-B; CELL-CYCLE ARREST; CD4(+) T-CELLS; TUMOR-NECROSIS-FACTOR; FAS LIGAND EXPRESSION; CASPASE-MEDIATED ACTIVATION; CHEMOKINE RECEPTOR CXCR4; BLOOD MONONUCLEAR-CELLS;
Keywords:
apoptosis; survival; HIV; vpr; net; tat; env; AIDS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
175
Recensione:
Indirizzi per estratti:
Indirizzo: Planelles, V Univ Rochester, Ctr Canc, Dept Med, 601 Elmwood Ave,Box 704, Rochester, NY14642 USA Univ Rochester 601 Elmwood Ave,Box 704 Rochester NY USA 14642
Citazione:
M. Roshal et al., "Apoptosis in AIDS", APOPTOSIS, 6(1-2), 2001, pp. 103-116

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) leads to progressive immunodeficiency and onset of opportunistic infections and neoplasms. The loss of immune competence is associated with declines in both the functionality and the number of CD4+ lymphocytes. Multiple mechanisms have been proposed to explain death and dysfunction of CD4+ T-cells. The mechanisms of HIV-1-mediated cell death which are relevant in vivo are unclear at present. However, in vitro explorations on the cytopathic effects of HIV-1 have yielded a wealth of potential triggering events, and signaling and effector pathways leading to apoptosis. The types of pro- and anti-apoptotic stimuli that have been associated with HIV-1 are multiple and often appear overlapping or even contradictory. This review focuses on the various molecular determinants from HIV-1 that play a role in induction of apoptosis in T-lymphocytes. Special attention is devoted to the viral genes, env, nef, tat and vpr, for which a significant body of literature on apotosis-related effects is available.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:01:59