Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neurodegenerative disorders and ischemic brain diseases
Autore:
Mattson, MP; Duan, W; Pedersen, WA; Culmsee, C;
Indirizzi:
NIA, Neurosci Lab, Baltimore, MD 21224 USA NIA Baltimore MD USA 21224NIA, Neurosci Lab, Baltimore, MD 21224 USA
Titolo Testata:
APOPTOSIS
fascicolo: 1-2, volume: 6, anno: 2001,
pagine: 69 - 81
SICI:
1360-8185(200102)6:1-2<69:NDAIBD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID BETA-PEPTIDE; FOCAL CEREBRAL-ISCHEMIA; NF-KAPPA-B; MANGANESE SUPEROXIDE-DISMUTASE; PROSTATE APOPTOSIS RESPONSE-4; METABOLIC EXCITOTOXIC INSULTS; PROTECTS HIPPOCAMPAL-NEURONS; TRANSIENT GLOBAL-ISCHEMIA; SUBSTANTIA-NIGRA COMPACTA; TROPHIC FACTOR WITHDRAWAL;
Keywords:
Alzheimer's disease; caspases; mitochondrial permeability transition; neurotrophic factors; oxidative stress; Parkinson's disease; telomerase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
145
Recensione:
Indirizzi per estratti:
Indirizzo: Mattson, MP Lab Neurosci 4F01, 5600 Nathan Shock Dr, Baltimore, MD 21224 USA Lab Neurosci 4F01 5600 Nathan Shock Dr Baltimore MD USA 21224
Citazione:
M.P. Mattson et al., "Neurodegenerative disorders and ischemic brain diseases", APOPTOSIS, 6(1-2), 2001, pp. 69-81

Abstract

Degeneration and death of neurons is the fundamental process responsible for the clinical manifestations of many different neurological disorders of aging, incuding Alzheimer's disease, Parkinson's disease and stroke. The death of neurons in such disorders involves apoptotic biochemical cascades involving upstream effectors (Par-4, p53 and pro-apoptotic Bcl-2 family members), mitochondrial alterations and caspase activation. Both genetic and environmental factors, and the aging process itself, contribute to intiation of such neuronal apoptosis. For example, mutations in the amyloid precursor protein and presenilin genes can cause Alzheimer's disease, while head injury is a risk factor for both Alzheimer's and Parkinson's diseases. At the cellular level, neuronal apoptosis in neurodegenerative disorders may be triggered by oxidative stress, metabolic compromise and disruption of calcium homeostasis. Neuroprotective (anti-apoptotic) signaling pathways involving neurotrophic factors, cytokines and "conditioning responses" can counteractthe effects of aging and genetic predisposition in experimental models of neurodegenerative disorders. A better understanding of the molecular underpinnings of neuronal death is leading directly to novel preventative and therapeutic approaches to neurodegenerative disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 13:01:51