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Titolo:
Novel vitamin K-dependent pathways regulating cell survival
Autore:
Saxena, SP; Israels, ED; Israels, LG;
Indirizzi:
Lovelace Resp Res Inst, Kirtland AFB, Albuquerque, NM 87115 USA Lovelace Resp Res Inst Albuquerque NM USA 87115 Albuquerque, NM 87115 USA Univ Manitoba, Manitoba Inst Cell Biol, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB Canada ba Inst Cell Biol, Winnipeg, MB, Canada Univ Manitoba, Dept Pediat, Winnipeg, MB, Canada Univ Manitoba Winnipeg MB Canada toba, Dept Pediat, Winnipeg, MB, Canada
Titolo Testata:
APOPTOSIS
fascicolo: 1-2, volume: 6, anno: 2001,
pagine: 57 - 68
SICI:
1360-8185(200102)6:1-2<57:NVKPRC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR TYROSINE KINASE; ARREST-SPECIFIC GENE-6; VASCULAR SMOOTH-MUSCLE; HORMONE-BINDING GLOBULIN; PROTEIN-S; TUMOR-CELLS; WARFARIN EMBRYOPATHY; CHONDRODYSPLASIA PUNCTATA; GAMMA-CARBOXYLATION; EXPRESSION ANALYSIS;
Keywords:
apoptosis; gamma-carboxylation; Gas6; protein S; receptor tyrosine kinases; vitamin K-1-dependent proteins;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
115
Recensione:
Indirizzi per estratti:
Indirizzo: Saxena, SP Lovelace Resp Res Inst, Kirtland AFB, Bldg 9200,Area Y, Albuquerque, NM 87115 USA Lovelace Resp Res Inst Bldg 9200,Area Y Albuquerque NM USA 87115
Citazione:
S.P. Saxena et al., "Novel vitamin K-dependent pathways regulating cell survival", APOPTOSIS, 6(1-2), 2001, pp. 57-68

Abstract

Historically, the vitamin K-1-dependent proteins have been associated primarily with blood coagulation and secondarily with bone formation. Recent identification of K-1-dependent proteins as specific ligands for the receptortyrosine kinases (RTKs) that can stimulate cell replication and transformation and participate in cell survival highlighted a previously unrecognizedand potentially important role for vitamin K-1 in cell signaling. Growing evidence suggests that most normal and tumor cells possess an active K-1-dependent gamma -carboxylation mechanism necessary for the production of gamma -carboxyglutamic acid (Gla)-containing proteins. Gla residues in proteinsfacilitate calcium-dependent protein/phospholipid interaction. Recent studies demonstrating the potentially positive effects of a vitamin K-dependentreceptor:ligand system on cell growth and survival in general and the effects of the overexpression of these RTKs on malignant cell survival provide a new perspective on the role of vitamin K-1, its dependent protein ligands, and their receptors. These cumulative observations also provide an explanation for the rigidly controlled K-1 levels in the mammalian fetus and the minimal hepatic stores in the adult.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 04:10:50