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Titolo:
Efficacy of a single diagnostic test for sensitization to common inhalant allergens
Autore:
Williams, PB; Siegel, C; Portnoy, J;
Indirizzi:
IBT Reference Lab, Lenexa, KS 66214 USA IBT Reference Lab Lenexa KS USA 66214 Reference Lab, Lenexa, KS 66214 USA Univ Missouri, Sch Med, Kansas City, MO 64108 USA Univ Missouri Kansas City MO USA 64108 Sch Med, Kansas City, MO 64108 USA
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 2, volume: 86, anno: 2001,
pagine: 196 - 202
SICI:
1081-1206(200102)86:2<196:EOASDT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM IGE LEVELS; SKIN PRICK TEST; PHADIATOP; RHINITIS; ASTHMA; HISTAMINE; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, PB IBT Reference Lab, 10453 W 84th Terrace, Lenexa, KS 66214 USAIBT Reference Lab 10453 W 84th Terrace Lenexa KS USA 66214 SA
Citazione:
P.B. Williams et al., "Efficacy of a single diagnostic test for sensitization to common inhalant allergens", ANN ALLER A, 86(2), 2001, pp. 196-202

Abstract

Background: UniCAP Phadiatop is a single laboratory test designed to determine the presence or absence of specific IgE to a variety of common inhalants. Its purpose is to aid in the differentiation of patients with symptoms attributable to allergic disease from other common causes. Methods: Consecutive children and adolescent patients (n = 145) at two centers were examined by having their history and physical examination performed by two board certified allergists. Their conclusions along with skin prick tests and specific IgE measurements regarding seven common inhalants (mite, oak, ragweed, grass, dog, cat, Alternaria) were compared with UniCAP Phadiatop test results. This was done using concordance of all test results. Attempts to resolve test discrepancies, when found, included specific RAST inhibitions, total IgE values, and physicians' judgment after testing. Results: All patients with resolved diagnoses (143 of 145, 103 positive and 40 negative) were identified correctly by the UniCAP Phadiatop test. Skintest results and specific IEE measurements correlated well, but neither correlated well with the history by itself, suggesting a minimal false-positive component of the history of 23%. UniCAP Phadiatop results demonstrated aquantitative relationship between the patient's score and the amount of IgE specific to these individual allergens. Conclusions: The UniCAP Phadiatop test was shown to be highly sensitive and specific in differentiating individuals who are sensitized to common inhalants from those who are not. This test is recommended to all physicians asan aid in diagnostic and referral decisions for patients suspected of having an inhalant allergic diathesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 08:26:20