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Titolo:
Measurement of cerebral hemodynamics with perfusion-weighted MR imaging: Comparison with pre- and post-acetazolamide Xe-133-SPECT in occlusive carotid disease
Autore:
Kikuchi, K; Murase, K; Miki, H; Kikuchi, T; Sugawara, Y; Mochizuki, T; Ikezoe, J; Ohue, S;
Indirizzi:
Ehime Univ, Sch Med, Dept Radiol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ, Sch Med, Dept Neurol Surg, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 2, volume: 22, anno: 2001,
pagine: 248 - 254
SICI:
0195-6108(200102)22:2<248:MOCHWP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; HIGH-RESOLUTION MEASUREMENT; INERT-GAS CONCENTRATIONS; TRACER BOLUS PASSAGES; BLOOD-FLOW; CEREBROVASCULAR-DISEASE; COMPUTED-TOMOGRAPHY; BYPASS-SURGERY; CONTRAST; VOLUME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kikuchi, K Ehime Univ, Sch Med, Dept Radiol, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Ehime 7910295, Japan
Citazione:
K. Kikuchi et al., "Measurement of cerebral hemodynamics with perfusion-weighted MR imaging: Comparison with pre- and post-acetazolamide Xe-133-SPECT in occlusive carotid disease", AM J NEUROR, 22(2), 2001, pp. 248-254

Abstract

BACKGROUND AND PURPOSE: We generated regional cerebral blood volume (rCBV)and regional cerebral blood flow (rCBF) studies from dynamic susceptibility contrast-enhanced MR images after an intravenous bolus injection of contrast agent (perfusion-weighted imaging [PWI]) by applying indicator dilutiontheory. We used a multishot echo-planar imaging (EPI) sequence to obtain adequate arterial input function (AIF). Our purpose was to compare the cerebral hemodynamics measured by PWI with the rCBF values and cerebral perfusion reserve obtained by xenon-133 single-photon emission CT (Xe-133-SPECT). METHODS: Eight patients with chronic internal carotid artery occlusion or stenosis were examined. PWI data were acquired using a multishot EPI sequence, and the AIF was determined automatically. Our procedure was based on indicator dilution theory and deconvolution analysis. To eliminate the effectof superficial vessels, the automatic threshold selection method was used. RESULTS: AIF was adequate to generate rCBF and rCBV images. The rCBF and rCBV images by PWI were superior to Xe-133-SPECT scans in spatial resolution, and the rCBF values obtained by PWI correlated well with those obtained by Xe-133-SPECT. The regions with severely decreased perfusion reserve, which were determined by pre- and post-acetazolamide Xe-133-SPECT, showed significantly lower rCBF and higher rCBV by PWI than did regions with normal andmoderately decreased perfusion reserve. CONCLUSION: The rCBF and rCBV images generated by bur procedure using PWI data appear to provide important clinical information for evaluating the degree of cerebral perfusion reserve impairment in patients with chronic ischemia.

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Documento generato il 23/01/20 alle ore 06:31:27