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Titolo:
Negative effect of ranitidine on the results of urea breath test for the diagnosis of Helicobacter pylori
Autore:
Savarino, V; Tracci, D; Dulbecco, P; Mele, MR; Zentilin, P; Mansi, C; Vigneri, S;
Indirizzi:
Univ Genoa, Dipartimento Med Interna & Specialita Med, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 na & Specialita Med, I-16132 Genoa, Italy Univ Palermo, Ist Med Interna & Specialita Med, Palermo, Italy Univ Palermo Palermo Italy Med Interna & Specialita Med, Palermo, Italy
Titolo Testata:
AMERICAN JOURNAL OF GASTROENTEROLOGY
fascicolo: 2, volume: 96, anno: 2001,
pagine: 348 - 352
SICI:
0002-9270(200102)96:2<348:NEOROT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID SUPPRESSION; C-13-UREA; OMEPRAZOLE; INFECTION; ACCURACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Savarino, V Univ Genoa, DIMI, Cattedra Gastroenterol, Viale Benedetto XV 6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto XV 6 Genoa Italy I-16132oa, Italy
Citazione:
V. Savarino et al., "Negative effect of ranitidine on the results of urea breath test for the diagnosis of Helicobacter pylori", AM J GASTRO, 96(2), 2001, pp. 348-352

Abstract

OBJECTIVES: In analogy with proton pump inhibitors, H2-antagonists may also be responsible for false-negative results on urea breath test for the detection of Helicobacter pylori. In this study we assessed the frequency and duration of false-negative urea breath tests in patients given different doses of ranitidine. METHODS: A total of 120 consecutive dyspeptic patients: infected with H. pylori on the basis of concomitant positive results of CLO-test, histology and urea breath test were: recruited for this prospective, open, parallel-group study performed in an urban university gastroenterological clinic. Theywere: randomized to receive an acute treatment with either ranitidine 300 mg once a day in the evening, ranitidine 300 mg once a day in the morning, ranitidine 150 mg b.i.d., or ranitidine 300 mg b.i.d. for 14 days. The ureabreath test was performed on day 14 while patients were still taking ranitidine, and on day 21, 1 wk after completion of therapy. The test was repeated on day 28 in those patients who were still negative on day 21. Duplicatebreath samples were collected after ingestion of 75 mg C-13-urea plus citric acid. A delta value >5 parts per thousand was considered positive. RESULTS: Of 118 patients infected with H. pylori, 15 (13%) had a negative urea breath test on day 14. The false-negative results were equally distributed among the four groups of ranitidine dosage. Nine of these patients: reverted to positive at 7 days and the remaining six at 14 days after completion of therapy. CONCLUSIONS: Our study shows that ranitidine negatively affects the results of urea breath testing, independent of the given dosage. Patients undergoing this examination for H. pylori diagnosis should discontinue use of H2-antagonists 2 wk before testing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:42:02