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Titolo:
Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients
Autore:
Mellerup, E; Bennike, B; Bolwig, T; Dam, H; Hasholt, L; Jorgensen, MB; Plenge, P; Sorensen, SA;
Indirizzi:
Rigshosp, Lab Neuropsychiat, Dept Psychiat, DK-2100 Copenhagen, Denmark Rigshosp Copenhagen Denmark DK-2100 sychiat, DK-2100 Copenhagen, Denmark Univ Copenhagen, Panum Inst, Inst Med Genet, DK-2200 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark
Titolo Testata:
ACTA PSYCHIATRICA SCANDINAVICA
fascicolo: 3, volume: 103, anno: 2001,
pagine: 229 - 233
SICI:
0001-690X(200103)103:3<229:PSTATT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANXIETY-RELATED TRAITS; AFFECTIVE-DISORDER; IMIPRAMINE BINDING; PAROXETINE BINDING; MAJOR DEPRESSION; FUNCTIONAL POLYMORPHISM; MOOD-DISORDERS; PAIN PATIENTS; ASSOCIATION; PROMOTER;
Keywords:
depression; platelet; serotonin transporter; serotonin transporter gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Mellerup, E Rigshosp, Lab Neuropsychiat, Dept Psychiat, 6102, DK-2100 Copenhagen, Denmark Rigshosp 6102 Copenhagen Denmark DK-2100 Copenhagen, Denmark
Citazione:
E. Mellerup et al., "Platelet serotonin transporters and the transporter gene in control subjects, unipolar patients and bipolar patients", ACT PSYC SC, 103(3), 2001, pp. 229-233

Abstract

Objective: The purpose of the present study was to relate the number of platelet serotonin transporters in unipolar and bipolar patients and in control subjects to two polymorphisms in the serotonin transporter gene: a VNTR in intron 2 and a deletion/insertion in the promoter region. Method: Density of platelet serotonin transporters was determined by radioligand binding analysis. Genotyping was performed by PCR amplification of polymorphic regions followed by size determination of the obtained fragments. Results: The control subjects and the two groups of patients were similar with respect to the genotype and allele distribution belonging to the two polymorphisms in the serotonin transporter gene for. An interaction between status (control, unipolar- or bipolar patient) and VNTR genotype regarding the number of platelet serotonin transporters was observed; unipolar patients with the genotype 12/10 had more platelet serotonin transporters than bipolar patients and controls with this genotype. No association related to the polymorphism was found in the promoter region of the serotonin transporter gene. Conclusion: An association was observed between the polymorphism in intron2 of the serotonin transporter gene and the number of platelet serotonin transporters. Unipolar patients with a particular genotype had more plateletserotonin transporters than the corresponding controls and bipolar patients.

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Documento generato il 23/01/20 alle ore 04:17:20