Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Aetiological factors in neonatal cholestasis
Autore:
Fischler, B; Papadogiannakis, N; Nemeth, A;
Indirizzi:
Huddinge Univ Hosp, Karolinska Inst, Dept Pediat, SE-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden SE-14186 t, SE-14186 Huddinge, Sweden Huddinge Univ Hosp, Karolinska Inst, Dept Pathol, S-14186 Huddinge, SwedenHuddinge Univ Hosp Huddinge Sweden S-14186 hol, S-14186 Huddinge, Sweden
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 1, volume: 90, anno: 2001,
pagine: 88 - 92
SICI:
0803-5253(200101)90:1<88:AFINC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRAHEPATIC BILIARY ATRESIA; FAMILIAL INTRAHEPATIC CHOLESTASIS; CYTOMEGALOVIRUS-INFECTION; HEPATITIS; INFANTS; LIVER; ASSOCIATION; DEFICIENCY; ETIOLOGY; DISEASE;
Keywords:
aetiology; extrahepatic biliary atresia; neonatal cholestasis; progressive familial intrahepatic cholestasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fischler, B Huddinge Univ Hosp, Karolinska Inst, Dept Pediat, SE-14186 Huddinge, Sweden Huddinge Univ Hosp Huddinge Sweden SE-14186 Huddinge, Sweden
Citazione:
B. Fischler et al., "Aetiological factors in neonatal cholestasis", ACT PAEDIAT, 90(1), 2001, pp. 88-92

Abstract

The aim of the study was to investigate factors of possible importance forthe aetiology of neonatal cholestasis. The medical records of 85 cholestatic infants were retrospectively reviewed. The most common diagnoses were extrahepatic biliary atresia (n = 30 patients), alpha (1)-antitrypsin deficiency (n = 11) and progressive familial intrahepatic cholestasis (n = 11). The mothers of the patients with biliary atresia had a higher mean age and were more commonly treated for gestational diabetes than the mothers of patients with intrahepatic neonatal cholestasis. The morbidity and mortality in the siblings of patients with biliary atresia were also greater than expected. There was a seasonal variation of the birth months in the biliary atresia group, possibly indicating an association to viral infections. Signs of ongoing cytomegalovirus infection were more common in both the extrahepaticand the intrahepatic group. Conclusions: Progressive familial intrahepatic cholestasis may be a more common cause of neonatal cholestasis in Sweden than reported elsewhere. A maternal vulnerability, of genetic or other origin, is suggested in the aetiology of biliary atresia. The true pathogenetic importance of cytomegalovirus infection in patients with neonatal cholestasis of different origins remains to be established.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:01:52