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Titolo:
TGF-beta in the cardiovascular system: Molecular mechanisms of a context-specific growth factor
Autore:
Topper, JN;
Indirizzi:
Stanford Univ, Sch Med, Dept Med, Div Cardiovasc, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iv Cardiovasc, Stanford, CA 94305 USA
Titolo Testata:
TRENDS IN CARDIOVASCULAR MEDICINE
fascicolo: 3, volume: 10, anno: 2000,
pagine: 132 - 137
SICI:
1050-1738(200004)10:3<132:TITCSM>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CREB-BINDING-PROTEIN; ENDOTHELIAL-CELLS; INDUCED TRANSCRIPTION; SMAD PROTEINS; CANCER CELLS; RECEPTOR; GENE; ACTIVATION; TGF-BETA-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Topper, JN COR Therapeut Inc, 256 E Grand Ave, S San Francisco, CA 94080 USA COR Therapeut Inc 256 E Grand Ave S San Francisco CA USA 94080
Citazione:
J.N. Topper, "TGF-beta in the cardiovascular system: Molecular mechanisms of a context-specific growth factor", TREND CARD, 10(3), 2000, pp. 132-137

Abstract

Transforming growth factor bera-l is the prototypical member of a class ofgrowth factors whose actions have been strongly implicated in a number of pathophysiologic processes including chronic vascular diseases such as atherosclerosis and hypertension. One of the hallmarks of this class of growth factors is the diverse nature of their actions; a characteristic that is thought to arise from the fact that the effects of these factors are very dependent upon the particular cellular context in which they operate. There has been substantial progress in understanding the molecular signaling mechanisms utilized by these factors. These findings ave beginning to provide a mechanistic framework with which to understand the complex and pleiotropic actions of these factors on cells and tissues of the cardiovascular system. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:31:21