Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Prominin: A story of cholesterol, plasma membrane protrusions and human pathology
Autore:
Corbeil, D; Roper, K; Fargeas, CA; Joester, A; Huttner, WB;
Indirizzi:
Univ Heidelberg, Interdisciplinary Ctr Neurosci, Dept Neurobiol, D-69120 Heidelberg, Germany Univ Heidelberg Heidelberg Germany D-69120 , D-69120 Heidelberg, Germany Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany Max PlanckInst Mol Cell Biol & Genet Dresden Germany D-01307 n, Germany
Titolo Testata:
TRAFFIC
fascicolo: 2, volume: 2, anno: 2001,
pagine: 82 - 91
SICI:
1398-9219(200102)2:2<82:PASOCP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELL ANTIGEN; SEGMENT DISK MEMBRANES; MOUSE KIDNEY PROMININ; EPITHELIAL-CELLS; HEMATOPOIETIC STEM; NEUROEPITHELIAL CELLS; CYTOPLASMIC DOMAIN; LIPID-COMPOSITION; DISTINCT MEMBER; PROTEIN FAMILY;
Keywords:
AC133 antigen; cholesterol; epithelial cell; membrane microdomain; microvilli; prominin; retinal degeneration; rod photoreceptor cell;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Huttner, WB Univ Heidelberg, Interdisciplinary Ctr Neurosci, Dept Neurobiol, Neuenheimer Feld 364, D-69120 Heidelberg, Germany Univ Heidelberg Neuenheimer Feld 364 Heidelberg Germany D-69120
Citazione:
D. Corbeil et al., "Prominin: A story of cholesterol, plasma membrane protrusions and human pathology", TRAFFIC, 2(2), 2001, pp. 82-91

Abstract

Prominin is the first identified member of a novel family of polytopic membrane proteins conserved throughout the animal kingdom. It has an unusual membrane topology, containing five transmembrane domains and two targe glycosylated extracellular loops. in mammals, prominin is expressed in Various embryonic and adult epithelial cells, as well as in nonepithelial cells, such as hematopoietic stem cells. At the subcellular level, prominin is selectively localized in microvilli and other plasma membrane protrusions, irrespective of cell type. At the molecular level, prominin specifically interacts with membrane cholesterol and is a marker of a novel type of cholesterol-based lipid 'raft'. A frameshift mutation in the human prominin gene, whichresults in a truncated protein that is no longer transported to the cell surface, is associated with retinal degeneration. Given that prominin is concentrated in the plasma membrane evaginations at the base of the outer segment of rod photoreceptor cells, which are essential precursor structures inthe biogenesis of photoreceptive disks, it is proposed that prominin has arole in the generation of plasma membrane protrusions, their lipid composition and organization and their membrane-to-membrane interactions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:30:43