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Titolo:
Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease
Autore:
Huse, JT; Doms, RW;
Indirizzi:
Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA Univ Penn, Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 t Dis Res, Philadelphia, PA 19104 USA
Titolo Testata:
TRAFFIC
fascicolo: 2, volume: 2, anno: 2001,
pagine: 75 - 81
SICI:
1398-9219(200102)2:2<75:NTUTMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-SECRETASE CLEAVAGE; PRECURSOR PROTEIN GENE; NEUROFIBRILLARY TANGLES; MISSENSE MUTATIONS; CULTURED-CELLS; PRESENILIN-1; EXPRESSION; FRAGMENTS; PEPTIDE; RELEASE;
Keywords:
Alzheimer's disease; amyloid-beta; amyloid precursor protein; beta-site APP-cleaving enzyme; endosomes; presenilin 1; presenilin 2; secretory pathway; trans-Golgi network;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Huse, JT Univ Penn, Dept Pathol & Lab Med, 806 Abramson,34th & Civ Ctr Blvd, Philadelphia, PA 19104 USA Univ Penn 806 Abramson,34th & Civ Ctr Blvd Philadelphia PA USA 19104
Citazione:
J.T. Huse e R.W. Doms, "Neurotoxic traffic: Uncovering the mechanics of amyloid production in Alzheimer's disease", TRAFFIC, 2(2), 2001, pp. 75-81

Abstract

Alzheimer's disease (AD) is thought by many to result from the accumulation of the neurotoxic amyloid-beta (A beta) peptide in brain parenchyma. The process by which AP is proteolytically derived from the larger amyloid precursor protein (APP) has been the focus of much attention in the AD researchfield over the past decade. Recently, several of the proteins directly involved in the generation of A beta have been identified and characterized providing a number of viable therapeutic targets for the treatment of AD. However, the cellular mechanisms by which these proteins interact in the proteolytic processing of APP have not been well defined, nor are they readily apparent when one considers what is known about the intracellular localization and trafficking of the various participants. This article will review the underlying cell biology of A beta production and discuss the mechanistic options for APP processing given the current knowledge of the proteases involved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 15:42:31