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Titolo:
Downregulation of the constitutive tapasin expression in human tumor cellsof distinct origin and its transcriptional upregulation by cytokines
Autore:
Seliger, B; Schreiber, K; Delp, K; Meissner, M; Hammers, S; Reichert, T; Pawlischko, K; Tampe, R; Huber, C;
Indirizzi:
Univ Mainz, Dept Internal Med 3, D-55101 Mainz, Germany Univ Mainz MainzGermany D-55101 Internal Med 3, D-55101 Mainz, Germany Dept Oral & Maxillofacial Surg, Mainz, Germany Dept Oral & Maxillofacial Surg Mainz Germany acial Surg, Mainz, Germany Univ Marburg, Sch Med, Inst Biochem Cellular Biochem & Biophys, Marburg, Germany Univ Marburg Marburg Germany llular Biochem & Biophys, Marburg, Germany
Titolo Testata:
TISSUE ANTIGENS
fascicolo: 1, volume: 57, anno: 2001,
pagine: 39 - 45
SICI:
0001-2815(200101)57:1<39:DOTCTE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MHC CLASS-I; HLA CLASS-I; ANTIGEN-PROCESSING TAP; IFN-GAMMA; TRANSPORTER; MOLECULES; COMPLEX; GENES; MECHANISMS; CARCINOMA;
Keywords:
antigen processing; cytokines; tapasin; tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Seliger, B Univ Mainz, Dept Internal Med 3, Langenbeckstr 1, D-55101 Mainz, Germany Univ Mainz Langenbeckstr 1 Mainz Germany D-55101 ainz, Germany
Citazione:
B. Seliger et al., "Downregulation of the constitutive tapasin expression in human tumor cellsof distinct origin and its transcriptional upregulation by cytokines", TISSUE ANTI, 57(1), 2001, pp. 39-45

Abstract

Human tumor cells frequently exhibit abnormalities in the major histocompatibility complex (MHC) class I surface expression which can be due to structural alterations and/or dysregulation of various components of the MHC class I antigen processing machinery, such as HLA class I heavy and light chains, the peptide transporter and the proteasome subunits. Although several cofactors critical for proper MHC class I assembly have been identified, their contribution to the immune escape phenotype of tumor cells has not been analyzed. In order to determine whether tapasin deficits are an integral part of immune escape mechanisms of human tumors, we studied the constitutiveand cytokine-regulated expression pattern of tapasin in malignant cells ofdistinct histology. Heterogeneous and reduced expression levels of tapasinwere found in small-cell lung carcinoma, pancreatic carcinoma, colon carcinoma, head an neck squamous cell carcinoma and renal cell carcinoma cell lines. Tapasin downregulation was also prominent in surgically removed tumor lesions when compared to normal controls. The impaired tapasin expression is often associated with low MHC class I cell surface expression. In addition, various cytokines, including interferon (IFN)-alpha, IFN-gamma, tumor necrosis factor (TNF)-alpha and interleukin (IL)-4, but not granulocyte-macrophage colony stimulating factor (GM-CSF), transcriptionally upregulate to adistinct extent and in a time-dependent manner tapasin expression in tumorcells. Thus, deficient tapasin expression appears to be a frequent event in human tumor cells. Its restoration by cytokines further suggests that impaired tapasin expression in tumors is rather due to dysregulation than to structural alterations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:58:41