Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
HYALURONIC-ACID SUPPRESSES FIBRONECTIN FRAGMENT MEDIATED CARTILAGE CHONDROLYSIS .2. IN-VIVO
Autore:
WILLIAMS JM; PLAZA V; HUI F; WEN C; KUETTNER KE; HOMANDBERG GA;
Indirizzi:
RUSH MED COLL,RUSH PRESBYTERIAN ST LUKES MED CTR,DEPT ANAT,600 S PAULINA ST,1653 W CONGRESS PKWY CHICAGO IL 60612
Titolo Testata:
Osteoarthritis and cartilage
fascicolo: 4, volume: 5, anno: 1997,
pagine: 235 - 240
SICI:
1063-4584(1997)5:4<235:HSFFMC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRA-ARTICULAR INJECTION; HIGH-MOLECULAR-WEIGHT; INTRAARTICULARLY APPLIED PAPAIN; SL-1010 SODIUM HYALURONATE; OSTEO-ARTHRITIS; CHONDROCYTE CULTURES; SYNOVIAL-FLUID; CLINICAL-TRIAL; CELL-MATRIX; OSTEOARTHRITIS;
Keywords:
FIBRONECTIN; CARTILAGE CHONDROLYSIS; HYALURONIC ACID; CARTILAGE REPAIR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Williams et al., "HYALURONIC-ACID SUPPRESSES FIBRONECTIN FRAGMENT MEDIATED CARTILAGE CHONDROLYSIS .2. IN-VIVO", Osteoarthritis and cartilage, 5(4), 1997, pp. 235-240

Abstract

Intra-articular sodium hyaluronic acid (KA) has been used as a treatment intervention in the management of osteoarthritis. It has been observed that KA can coat the articular surface, and thus, has been suggested to provide a possible prophylactic barrier for the articular cartilage. In an accompanying manuscript (Homandberg et al.), we report that a commercially available high-molecular-weight HA (approximately 800-kDa, ARTZ, Seikagaku Corp.) can partially block fibronectin fragment (Fn-f)-mediated cartilage injury in vitro. Herein we report a study ofthe effects of intra-articular HA on an in vivo animal model of Fn-f-mediated cartilage injury. Rabbit knees were injected with Fn-f, and after 1 week, the cartilage proteoglycan (PG) content had decreased to 59 +/- 8% of control. In sharp contrast, PG content in knees receivingpre-treatment with HA followed by Fn-f injection had only decreased to 85 +/- 27% of control (P < 0.01). Similarly, the PG; content in knees receiving an injection of Fn-f, followed by an injection of HA were significantly higher (74 +/- 18% of control) than Fn-f injured knees with no treatment (P < 0.02). Intra-articular KA alone had no effect oncartilage PG content. The results in this study suggest that HA is effective in partially preventing Fn-f mediated cartilage injury, most likely by coating the articular surface. Further, HA treatment after Fn-f injury may facilitate restoration of matrix components.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 19:08:49