Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Design of multistable RNA molecules
Autore:
Flamm, C; Hofacker, IL; Maurer-Stroh, S; Stadler, PF; Zehl, M;
Indirizzi:
Univ Vienna, Inst Theoret Chem & Mol Strukturbiol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 l Strukturbiol, A-1090 Vienna, Austria Santa Fe Inst, Santa Fe, NM 87501 USA Santa Fe Inst Santa Fe NM USA 87501Santa Fe Inst, Santa Fe, NM 87501 USA
Titolo Testata:
RNA-A PUBLICATION OF THE RNA SOCIETY
fascicolo: 2, volume: 7, anno: 2001,
pagine: 254 - 265
SICI:
1355-8382(200102)7:2<254:DOMRM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
Q-BETA REPLICASE; SECONDARY STRUCTURES; RIBOSOMAL-RNA; BACILLUS-SUBTILIS; NEUTRAL NETWORKS; MESSENGER-RNA; SEQUENCE; BINDING; CONFORMATION; PREDICTIONS;
Keywords:
RNA folding; RNA secondary structure prediction; RNA switches; sequence design;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Hofacker, IL Univ Vienna, Inst Theoret Chem & Mol Strukturbiol, Wahringerstr 17, A-1090Vienna, Austria Univ Vienna Wahringerstr 17 Vienna Austria A-1090 a, Austria
Citazione:
C. Flamm et al., "Design of multistable RNA molecules", RNA, 7(2), 2001, pp. 254-265

Abstract

We show that the problem of designing RNA sequences that can fold into multiple stable secondary structures can be transformed into a combinatorial optimization problem that can be solved by means of simple heuristics. Henceit is feasible to design RNA switches with prescribed structural alternatives. We discuss the theoretical background and present an efficient tool that allows the design of various types of switches. We argue that both the general properties of the sequence structure map of RNA secondary structuresand the ease with which our design tool finds bistable RNAs strongly indicates that RNA switches are easily accessible in evolution. Thus conformational switches are yet another function for which RNA can be employed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:51:33