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Titolo:
The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage
Autore:
Takahashi, T; Yamaguchi, E; Furuya, K; Kawakami, Y;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Med 1, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 2, volume: 95, anno: 2001,
pagine: 130 - 135
SICI:
0954-6111(200102)95:2<130:TAGPAC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING-ENZYME; INSERTION DELETION POLYMORPHISM; INHIBITOR COUGH; SUBSTANCE-P; INTRADERMAL BRADYKININ; LINKAGE ANALYSIS; SENSORY NERVES; GUINEA-PIGS; SERUM; SEGREGATION;
Keywords:
ACE gene polymorphism; ACE inhibitor; cough; bradykinin; substance P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, E Hokkaido Univ, Sch Med, Dept Med 1, Kita Ku, N-15 W-7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N-15 W-7 Sapporo Hokkaido Japan 0608638 , Japan
Citazione:
T. Takahashi et al., "The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage", RESP MED, 95(2), 2001, pp. 130-135

Abstract

Persistent dry cough is an occasional but clinically important adverse reaction to angiotensin I-converting enzyme (ACE) inhibitors (ACEI). Its reported incidence is variable, and why cough occurs in only certain individualshas been unclear. An insertion/deletion (I/D) polymorphism of the ACE geneis associated with serum ACE activity. We have previously shown that susceptibility to cough induced by ACEI is associated with this polymorphism such that patients with genotype II are more susceptible to cough than patients with other genotypes. In order to confirm and extend our previous observation, we conducted a randomized, placebo-controlled, double-blind, cross-oler study in 10 healthy volunteers with genotype II and 10 with genotype DD. The cough threshold was determined by the concentration of inhaled capsaicin causing two or more coughs. After the usage of an ACEI, cilazapril, for4 weeks, changes in the cough threshold in subjects with genotype II [before: 6.6 +/- 3.7 nM (mean +/- SD); after: 5.0 +/- 4.6 nM] significantly differed from those in subjects with genotype DD (before: 9.0 +/- 9.4 nM; after: 9.3 +/- 9.1 nM). Skin responses to intradermal bradykinin, which is a substrate of ACE and tussigenic, were significantly increased in subjects withgenotype II (before: 1.6 +/- 0.6 vs. after: 2.6 +/- 0.5 cm(2), P < 0.05) but not in subjects with genotype DD (before: 1.4 +/- 0.5 vs. after: 1.6 +/-0.6 cm(2), n.s.) after usage of cilazapril. By contrast, skin responses tointradermal substance P did not change in subjects with either genotype. These findings provide further evidence of a link between ACEI-induced coughand I/D polymorphism of the ACE gene and suggest that ACEIs induce cough by modulating the tissue level of bradykinin.

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Documento generato il 15/08/20 alle ore 19:48:14