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Titolo:
The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats
Autore:
Alderson, HL; Parkinson, JA; Robbins, TW; Everitt, BJ;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 153, anno: 2001,
pagine: 455 - 463
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; KAPPA-OPIOID RECEPTORS; KAINIC ACID LESIONS; DOPAMINE TRANSMISSION; OPIATE RECEPTORS; PLACE-PREFERENCE; FOOD-STIMULI; COCAINE; MORPHINE; PERFORMANCE;
Keywords:
addiction; drug taking; reward; learning; opiate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Everitt, BJ Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB , England
Citazione:
H.L. Alderson et al., "The effects of excitotoxic lesions of the nucleus accumbens core or shell regions on intravenous heroin self-administration in rats", PSYCHOPHAR, 153(4), 2001, pp. 455-463

Abstract

Rationale: It has been suggested that the nucleus accumbens (NAcc) may be involved in heroin reward, and the core and shell regions respond differently following administration of a number of drugs of abuse. Objective: The possible role of the NAcc core and shell subregions in the acquisition of heroin self-administration behaviour was investigated. Methods: Rats were given selective excitotoxic lesions of either the nucleus accumbens core or shell before the acquisition of responding for IV heroin (0.04 mg/infusion) under a continuous reinforcement schedule in daily 3 h sessions. After sham-lesioned rats reached a stable baseline, a between-sessions heroin dose-response function was established. Results: Rats with lesions of the NAcc shell did not differ significantly from sham controls in either the acquisitionof heroin self-administration or in their heroin dose-response function. The NAcc core lesion group showed reduced levels of responding during the acquisition of heroin self-administration and a reduction in responding during the heroin dose-response function, although this behaviour was sensitive to changes in the dose of heroin. Conclusions: The NAcc shell does not appear to be critical for heroin self-administration, whereas the NAcc core, although apparently not essential in mediating the rewarding effect of IV heroin, may mediate processes that are of special importance during the acquisition of instrumental behaviour.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 00:07:44