Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Pharmacological evidence supporting a role for galanin in cognition and affect
Autore:
Wrenn, CC; Crawley, JN;
Indirizzi:
NIMH, Sect Behav Neuropharmacol, Expt Therapeut Branch, Bethesda, MD 20892USA NIMH Bethesda MD USA 20892 , Expt Therapeut Branch, Bethesda, MD 20892USA
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 25, anno: 2001,
pagine: 283 - 299
SICI:
0278-5846(200101)25:1<283:PESARF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRAL HIPPOCAMPUS; NONMATCHING-TO-SAMPLE; MEDIAL SEPTAL AREA; SPONTANEOUS-ALTERNATION PERFORMANCE; NUCLEUS BASALIS MAGNOCELLULARIS; LOCUS-COERULEUS NEURONS; CENTRAL NERVOUS-SYSTEM; ACETYLCHOLINE-RELEASE; TYROSINE-HYDROXYLASE; ALZHEIMERS-DISEASE;
Keywords:
acetylcholine; Alzheimer's; anxiety; depression; galanin; glutamate; learning; memory; neuropeptide; rodent;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Crawley, JN NIMH, Sect Behav Pharmacol, Bldg 10,Room 4D11, Bethesda, MD 20892 USA NIMH Bldg 10,Room 4D11 Bethesda MD USA 20892 sda, MD 20892 USA
Citazione:
C.C. Wrenn e J.N. Crawley, "Pharmacological evidence supporting a role for galanin in cognition and affect", PROG NEUR-P, 25(1), 2001, pp. 283-299

Abstract

1. Galanin is localized in brain pathways involved in both cognition and affect.2. Galanin has inhibitory actions on a variety of memory tasks including the Morris water maze, delayed nonmatching to position, T-maze delayed alternation, starburst maze, passive avoidance, active avoidance, and spontaneous alternation.3. Galanin may inhibit learning and memory by inhibiting neurotransmitter release and neuronal firing rate.4. Two signal transduction mechanisms through which galanin exerts its inhibitory actions are the inhibition of phosphatidyl inositol hydrolysis and the inhibition of adenylate cyclase.5. Galanin released during periods of burst firing from noradrenergic locus coeruleus terminals in the ventral tegmental area (VTA) may lead to symptoms of depression through inhibition of dopaminergic VTA neurons.6. Intraventricular galanin has anxiolytic effects in a punished drinking test. Intra-amygdala galanin has anxiogenic effects in a punished drinking test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 23:42:39