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Titolo:
The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes
Autore:
Morel, L; Blenman, KR; Croker, BP; Wakeland, EK;
Indirizzi:
Univ Florida, Dept Med, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Dept Med, Gainesville, FL 32610 USA Univ Florida, Dept Pathol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 t Pathol, Gainesville, FL 32610 USA N Florida S George Vet Hlth Syst, Gainesville, FL 32608 USA N Florida S George Vet Hlth Syst Gainesville FL USA 32608 e, FL 32608 USA Univ Texas, SW Med Ctr, Ctr Immunol, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Med Ctr, Ctr Immunol, Dallas, TX 75235 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 4, volume: 98, anno: 2001,
pagine: 1787 - 1792
SICI:
0027-8424(20010213)98:4<1787:TMMSLE>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENIC MOUSE STRAINS; DISSECTION; PATHOGENESIS; MICE; AUTOIMMUNITY; NEPHRITIS; AUTOANTIBODIES; CHROMOSOME-4; TOLERANCE; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Morel, L Univ Florida, Dept Med, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Gainesville, FL 32610 USA
Citazione:
L. Morel et al., "The major murine systemic lupus erythematosus susceptibility locus, Sle1, is a cluster of functionally related genes", P NAS US, 98(4), 2001, pp. 1787-1792

Abstract

The major murine systemic lupus erythematosus (SLE) susceptibility locus Sle1 is syntenic to a chromosomal region linked with SLE susceptibility in multiple human studies. Congenic analyses have shown that sie 1 breaks tolerance to chromatin, a necessary step for full disease induction that can be suppressed by specific modifier loci. In the present study, our fine mapping analysis of the location of Sle1 has determined that th ree loci within th is congenic interval, termed Sle1a, Sle1b, and Sle1c, can independently cause a loss of tolerance to chromatin, Each displays a distinctive profile of serological and cellular characteristics, with T and B cell functions being more affected by Sle1a and Sle1b, respectively. The epistatic interactions of Sle1 with other susceptibility loci to cause severe nephritis cannotbe accounted, however, by these three loci alone, suggesting the existenceof an additional locus, termed Sle1d. These findings indicate that the potent autoimmune phenotype caused by the Sle1 genomic interval reflects the combined impact of four, separate, susceptibility genes. This level of genetic complexity, combined with similar findings in other systems, supports the possibility that many complex trait loci reflect the impact of polymorphisms in linked clusters of genes with related functions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:12:08