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Titolo:
Antiosteoporotic activity of Dae-Bo-Won-Chun in ovariectomized rats
Autore:
Chae, HJ; Kang, JS; Kim, JH; Kim, CW; Yoo, SK; Shin, TY; Choi, B; Kim, HM; Kim, HR;
Indirizzi:
Wonkwang Univ, Dept Dent Pharmacol, Sch Dent, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 70749, Chonbuk, SouthKorea Sch Dent, Wonkwang Dent Res Inst, Iksan 570749, Chonbuk, South Korea Sch Dent Iksan Chonbuk South Korea 570749 an 570749, Chonbuk, South Korea Woosuk Univ, Coll Pharm, Wanju 565701, Chonbuk, South Korea Woosuk Univ Wanju Chonbuk South Korea 565701 565701, Chonbuk, South Korea Wonkwang Univ, Ctr Oriental Med Sci, Sch Pharm, Dept Oriental Pharm, Iksan570749, Chonbuk, South Korea Wonkwang Univ Iksan Chonbuk South Korea 570749 0749, Chonbuk, South Korea
Titolo Testata:
PHYTOTHERAPY RESEARCH
fascicolo: 1, volume: 15, anno: 2001,
pagine: 53 - 57
SICI:
0951-418X(200102)15:1<53:AAODIO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL OSTEOPOROSIS; ESTROGEN; CALCIUM; METABOLISM;
Keywords:
ovariectomy; DBWC; serum biochemistry; bone histomorphometry; mechanical strength;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HR Wonkwang Univ, Dept Dent Pharmacol, Sch Dent, Iksan 570749, Chonbuk, SouthKorea Wonkwang Univ Iksan Chonbuk South Korea 570749 honbuk, SouthKorea
Citazione:
H.J. Chae et al., "Antiosteoporotic activity of Dae-Bo-Won-Chun in ovariectomized rats", PHYTOTHER R, 15(1), 2001, pp. 53-57

Abstract

The preventive effect of the herbal formulation, 'Dae-Bo-Won-Chun' (DBWC),on the progress of bone loss induced by ovariectomy (OVX) was studied in rats. From light microscope analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in ovariectomized rats, whereas those of the same bone in sham-operated rats were composed of fine particles, The trabecular bone area and trabecular thickness in ovariectomized rats decreased by 50% from those in sham-operated rats, these decreases were completely inhibited by administration of DBWC at a concentration of 10mg/kg per day for 7 weeks. The mechanical strength of the neck of the femur was decreased by ovariectomy, and this was significantly suppressed by the administration of DBWC, Serum phosphorus, alkaline phosphatase and thyroxine levels in ovariectomized rats increased compared with those in sham-operated rats, and increases were completely inhibited by the administration of DBWC, These results strongly suggest that DBWC is effective in preventingthe development of bone loss induced by ovariectomy in rats. Copyright (C)2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 08:43:13