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Titolo:
INCREASED REJECTION OF MURINE ALLOGENEIC BONE-MARROW IN PRESENSITIZEDRECIPIENTS
Autore:
VANOS R; DEWITTE T; DILLINGH JH; MAUCH PM; DOWN JD;
Indirizzi:
HARVARD UNIV,SCH MED,JOINT CTR RADIAT THERAPY,330 BROOKLINE AVE BOSTON MA 02215 UNIV GRONINGEN,DEPT RADIOBIOL GRONINGEN NETHERLANDS UNIV NIJMEGEN,DIV HEMATOL NIJMEGEN NETHERLANDS
Titolo Testata:
Leukemia
fascicolo: 7, volume: 11, anno: 1997,
pagine: 1045 - 1048
SICI:
0887-6924(1997)11:7<1045:IROMAB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL-BODY IRRADIATION; SEVERE APLASTIC-ANEMIA; GRAFT-REJECTION; HOST DISEASE; DOSE-RATE; T-CELLS; TRANSPLANTATION; ENGRAFTMENT; LYMPHOCYTES; MICE;
Keywords:
PRESENSITIZATION; T CELL DEPLETION; ALLOGENEIC; BONE MARROW TRANSPLANTATION; TOTAL BODY IRRADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
R. Vanos et al., "INCREASED REJECTION OF MURINE ALLOGENEIC BONE-MARROW IN PRESENSITIZEDRECIPIENTS", Leukemia, 11(7), 1997, pp. 1045-1048

Abstract

The role of presensitizing murine recipients with donor spleen cells prior to T cell-depleted or -repleted H-2 compatible allogeneic bone marrow transplantation (BMT) was investigated at two different doses oftotal body irradiation (TBI). Recipients that were presensitized with2 x 10(7) irradiated donor spleen cells at 1 week before a sublethal dose of 6 Gy TBI and BMT showed no evidence of donor blood chimerism while unsensitized recipients showed about 80% donor engraftment as determined by blood Gpi phenotyping. After raising the TBI dose to 9.5 Gyan increase in mortality from marrow failure was observed in presensitized animals. No significant engraftment-promoting effect of up to 2 x 10(6) T cells (20% of total marrow dose) was seen either in presensitized or unsensitized mice. It can be concluded that presensitized recipients are more susceptible to acute marrow rejection and that T cells added to the bone marrow did not influence the level of donor engraftment in these recipients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 18:48:45