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Titolo:
RECURRING PROVIRAL INTEGRATION SUGGESTS A ROLE FOR PROTOONCOGENE ACTIVATION IN THYMOMAS INDUCED WITH MO-MULV-RESCUED BCR ABL VIRUS/
Autore:
CLARK SS;
Indirizzi:
UNIV WISCONSIN,DEPT HUMAN ONCOL,600 HIGHLAND AVE MADISON WI 53792 UNIV WISCONSIN,CTR COMPREHENS CANC MADISON WI 53792
Titolo Testata:
Leukemia
fascicolo: 7, volume: 11, anno: 1997,
pagine: 1026 - 1033
SICI:
0887-6924(1997)11:7<1026:RPISAR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MURINE LEUKEMIA-VIRUS; T-CELL LYMPHOMAS; BCR-ABL ONCOGENE; INFECTED LYMPHOCYTES; PHILADELPHIA-CHROMOSOME; HEMATOPOIETIC-CELLS; CLONAL LINES; HELPER VIRUS; MYC ONCOGENE; RAT THYMOMAS;
Keywords:
ONCOGENE; PROTOONCOGENE; A-MULV; MO-MULV; BCR/ABL THYMOMA; AHI-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
S.S. Clark, "RECURRING PROVIRAL INTEGRATION SUGGESTS A ROLE FOR PROTOONCOGENE ACTIVATION IN THYMOMAS INDUCED WITH MO-MULV-RESCUED BCR ABL VIRUS/", Leukemia, 11(7), 1997, pp. 1026-1033

Abstract

Intrathymic injection of Moloney murine leukemia virus (Mo-MuLV)-pseudotyped bcr-abl retrovirus (bcr-abl/M) causes thymic lymphoma but onlyafter a prolonged latent period similar to that seen after intrathymic injection of Mo-MuLV alone. Since thymomas induced by Mo-MuLV show recurring proviral integration near certain cellular proto-oncogenes, it was reasoned that if the pathogenesis of bcr-abl/M thymomas is affected by viral integration, then it may be possible to detect proviral insertion near common Mo-MuLV integration sites in bcr-abl-induced thymomas. A panel of thymomas induced by intrathymic injection of Mo-MuLV,Abelson murine leukemia virus (A-MuLV), or the bcr-abl/M virus was analyzed for proviral integration near c-myc, N-myc, Pim-1, and Mivi-1 loci that are frequently occupied by provirus in Mo-MuLV-induced T celllymphomas, and for integration near Ahi-1 that is often occupied in A-MuLV/M-induced pre-B cell lymphoma. As expected, thymomas induced with Mo-MULV showed frequent rearrangements in these loci while thymomas induced with A-MuLV/M (which does not require Mo-MuLV) did not. The bcr-abl/M-induced tumors also showed recurring proviral integration nearc-myc, Pim-1 and Mivi-1, albeit at a lower frequency than seen in theMo-MuLV tumors. Unexpectedly, four independent thymomas that were clearly of T cell origin demonstrated proviral integration within the Ahi-1 region which was previously thought to only occur in A-MuLV/M induced pre-B cell lymphoma, These observations suggest that recurring proviral insertion in c-myc, Pim-1, Mivi-1, and Ahi-1 may provide a selective advantage for bcr-abl/M transformed T lymphoid cells. This model may provide a tool for identifying cellular genes that can cooperate with bcr-abl in lymphoid transformation.

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Documento generato il 29/11/20 alle ore 03:28:32