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Titolo:
Plasma prorenin levels may predict persistent microalbuminuria in childrenwith diabetes
Autore:
Chiarelli, F; Pomilio, M; De Luca, FA; Vecchiet, J; Verrotti, A;
Indirizzi:
Osped Policlin, Pediat Clin, I-66100 Chieti, Italy Osped Policlin ChietiItaly I-66100 , Pediat Clin, I-66100 Chieti, Italy Univ Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Chieti Chieti Italy iv Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Messina, Dept Pediat, Messina, Italy Univ Messina Messina ItalyUniv Messina, Dept Pediat, Messina, Italy
Titolo Testata:
PEDIATRIC NEPHROLOGY
fascicolo: 2, volume: 16, anno: 2001,
pagine: 116 - 120
SICI:
0931-041X(200102)16:2<116:PPLMPP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INACTIVE RENIN; MELLITUS; NEPHROPATHY; COMPLICATIONS; MARKER; NEUROPATHY; RISK;
Keywords:
type 1 diabetes mellitus; prorenin; renin; microalbuminuria; diabetic nephropathy; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Chiarelli, F Osped Policlin, Pediat Clin, Via Vestini 5, I-66100 Chieti, Italy Osped Policlin Via Vestini 5 Chieti Italy I-66100 eti, Italy
Citazione:
F. Chiarelli et al., "Plasma prorenin levels may predict persistent microalbuminuria in childrenwith diabetes", PED NEPHROL, 16(2), 2001, pp. 116-120

Abstract

Diabetic microangiopathy is characterized by increased prorenin concentrations. In the present study, we evaluated plasma prorenin concentrations in a large group of adolescents with onset of diabetes during childhood to determine whether increasing prorenin levels may predict the development of persistent microalbuminuria. Ninety-seven young diabetic patients were studied; they were divided according to the presence of persistent microalbuminuria, at the end of follow-up, into group A and group B (patients who did notdevelop and who developed persistent microalbuminuria, respectively). One hundred and two healthy subjects, matched for age and sex, were also selected. Patients were followed up for at least 10 years. At the beginning of the study there were no significant differences in prorenin levels between either the two diabetic groups or the healthy controls. During follow-up, an increase in plasma prorenin started at 4 years and became statistically significant (P<0.01) 3 years before the onset of persistent microalbuminuria. No correlation was found between plasma prorenin levels and HbA1c percentages. In conclusion, an increased concentration of prorenin in plasma precedes the elevation of albumin excretion rate (AER) and, therefore, can be useful for identifying patients with onset of diabetes during childhood at riskof developing incipient nephropathy later in life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:48:32