Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Cooperation of NMDA and tachykinin NK1 and NK2 receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach
Autore:
Jocic, M; Schuligoi, R; Schoninkle, E; Pabst, MA; Holzer, P;
Indirizzi:
Graz Univ, Dept Expt & Clin Pharmacol, A-8010 Graz, Austria Graz Univ Graz Austria A-8010 xpt & Clin Pharmacol, A-8010 Graz, Austria Graz Univ, Dept Histol & Embryol, A-8010 Graz, Austria Graz Univ Graz Austria A-8010 ept Histol & Embryol, A-8010 Graz, Austria
Titolo Testata:
PAIN
fascicolo: 2-3, volume: 89, anno: 2001,
pagine: 147 - 157
SICI:
0304-3959(200101)89:2-3<147:CONATN>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-TRACTUS-SOLITARII; NITRIC-OXIDE SYNTHASE; IMMEDIATE-EARLY GENES; FOS MESSENGER-RNA; SUBSTANCE-P; GASTROINTESTINAL-TRACT; NEUROKININ-1 RECEPTOR; SPINAL-CORD; BRAIN-STEM; IN-VITRO;
Keywords:
gastric mucosal acid insult; expression of c-fos mRNA; area postrema; nucleus of the solitary tract; NMDA-type glutamate receptor; tachykinin NK1 receptor; tachykinin NK2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Holzer, P Graz Univ, Dept Expt & Clin Pharmacol, Univ Pl 4, A-8010 Graz, Austria Graz Univ Univ Pl 4 Graz Austria A-8010 4, A-8010 Graz, Austria
Citazione:
M. Jocic et al., "Cooperation of NMDA and tachykinin NK1 and NK2 receptors in the medullary transmission of vagal afferent input from the acid-threatened rat stomach", PAIN, 89(2-3), 2001, pp. 147-157

Abstract

Noxious challenge of the rat gastric mucosa by hydrochloric acid (HCl) is signaled to the nucleus tractus solitarii (NTS) and area postrema (AP). This study examined the participation of glutamate and tachykinins in the medullary transmission process. Activation of neurons was visualized by in situhybridization autoradiography of c-fos messenger RNA (mRNA) 45 min after intragastric (IG) administration of 0.5 M HCl or saline. IG HCl caused many neurons in the NTS and some neurons in the AP to express c-fos mRNA. The NMDA glutamate receptor antagonist MK-801 (2 mg/kg), the NK1 tachykinin receptor antagonist GR-205,171 (3 mg/kg) and the NK2 receptor antagonist SR-144,190 (0.1 mg/kg) failed to significantly reduce the NTS response to IG HCl, whereas the triple combination of MK-801, GR-205,171 and SR-144,190 inhibited it by 45-50%. Only in rats that had been preexposed IG to HCl 48 h before the experiment was MK-801 alone able to depress the NTS response to IG HCl. In contrast, the c-fos mRNA response in the AP was significantly augmented by MK-801, an action that was prevented by coadministration of GR-205,171 plus SR-144,190. Inhibition of neuronal nitric oxide synthase with 7-nitroindazole (45 mg/kg) was without effect on the IG HCl-evoked c-fos mRNA expression in the NTS and AP. Our data show that glutamate acting via NMDA receptors and tachykinins acting via NK1 and NK2 receptors cooperate in the vagal afferent input from the acid-threatened stomach to the NTS and participate in the processing of afferent input to the AP in a different and complex manner. These opposing interactions in the AP and NTS and the increase inNMDA receptor function in the NTS after a gastric acid insult are likely to have a bearing on the neuropharmacology of dyspepsia. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 08:17:09