Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of diclofenac in the rat tail ischaemia-reperfusion injury model of acute hyperalgesia
Autore:
Grace, RF; Lin, YG; Edwards, SR; Power, I; Mather, LE;
Indirizzi:
Univ Sydney, Royal N Shore Hosp, Dept Anaesthesia & Pain Management, St Leonards, NSW 2065, Australia Univ Sydney St Leonards NSW Australia 2065 Leonards, NSW 2065, Australia
Titolo Testata:
PAIN
fascicolo: 2-3, volume: 89, anno: 2001,
pagine: 117 - 125
SICI:
0304-3959(200101)89:2-3<117:EODITR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HORN CONVERGENT NEURONS; SKIN TEMPERATURE; SPINAL-CORD; CYCLOOXYGENASE INHIBITORS; RECEPTIVE-FIELDS; FORMALIN TEST; MOUSE-BRAIN; FLICK TEST; ISCHEMIA;
Keywords:
diclofenac; non-steroidal anti-inflammatory drug; hyperalgesia; ischemia; reperfusion injury; prostaglandin; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Mather, LE Univ Sydney, Royal N Shore Hosp, Dept Anaesthesia & Pain Management, St Leonards, NSW 2065, Australia Univ Sydney St Leonards NSW Australia 2065 NSW 2065, Australia
Citazione:
R.F. Grace et al., "Effects of diclofenac in the rat tail ischaemia-reperfusion injury model of acute hyperalgesia", PAIN, 89(2-3), 2001, pp. 117-125

Abstract

The rat tail ischaemia-reperfusion model of acute hyperalgesia described by Gelgor et al. (Pain 24 (1986) 251) has been investigated pharmacologically and electrophysiologically. Despite the advantages of this reusable animal model, biochemical changes associated with the behavioural response have not been determined. After injury +/- subcutaneous: diclofenac pretreatment, we investigated the behavioural response (changes to thermally-induced tail flick latency) and measured diclofenac, prostaglandin E-2, 6-keto-prostaglandin F-1 alpha and thromboxane B-2 concentrations in the tail, spinal cord and brain. Subcutaneous injection of 40 mg kg(-1) diclofenac sodium abolished the hyperalgesic response, suppressed the increased eicosanoid production in the tail, inhibited eicosanoid synthesis in the brain, but gave equivocal effects on eicosanoid concentrations in the spinal cord. Injection of 10 and 20 mg kg(-1) diclofenac reduced the duration of hyperalgesia but did not abolish the behavioural response. Diclofenac concentrations in all three tissues were similar, being similar to5-10% of the corresponding plasma concentrations. We propose that both central and peripheral mechanisms are associated with the hyperalgesia and that the findings lend indirect support to a central action for non-steroidal anti-inflammatory drugs. (C) 2001International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:05:07