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Titolo:
Cross-sectional comparison of synovial fluid biochemical markers in equineosteoarthritis and the correlation of these markers with articular cartilage damage
Autore:
Fuller, CJ; Barr, AR; Sharif, M; Dieppe, PA;
Indirizzi:
Univ Bristol, Dept Vet Clin Sci, Bristol BS40 5DU, Avon, England Univ Bristol Bristol Avon England BS40 5DU ristol BS40 5DU, Avon, England Univ Bristol, Dept Med, Bristol BS40 5DU, Avon, England Univ Bristol Bristol Avon England BS40 5DU ristol BS40 5DU, Avon, England Univ Bristol, Dept Med, Dept Social Med, Bristol BS40 5DU, Avon, England Univ Bristol Bristol Avon England BS40 5DU ristol BS40 5DU, Avon, England
Titolo Testata:
OSTEOARTHRITIS AND CARTILAGE
fascicolo: 1, volume: 9, anno: 2001,
pagine: 49 - 55
SICI:
1063-4584(200101)9:1<49:CCOSFB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBCHONDRAL BONE CHANGES; ALKALINE-PHOSPHATASE; KERATAN SULFATE; ARTHROSCOPIC FINDINGS; KNEE; SERUM; DISEASE; HORSES; GLYCOSAMINOGLYCANS; ABNORMALITIES;
Keywords:
osteoarthritis; biochemical markers; cartilage; equine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fuller, CJ Univ Bristol, Dept Vet Clin Sci, Langford House, Bristol BS40 5DU, Avon, England Univ Bristol Langford House Bristol Avon England BS40 5DUgland
Citazione:
C.J. Fuller et al., "Cross-sectional comparison of synovial fluid biochemical markers in equineosteoarthritis and the correlation of these markers with articular cartilage damage", OSTEO CART, 9(1), 2001, pp. 49-55

Abstract

Objective: To investigate the relationship between biochemical markers in the synovial fluid of osteoarthritic and contralateral equine joints and gross articular cartilage pathology. Design: Twenty-two horses underwent bilateral arthroscopy of their carpal or metacarpophalangeal joints following recent onset lameness. The degree of cartilage damage in each joint was scored and synovial fluid, from both the clinically affected and the contralateral joint, was collected. Bone specific alkaline phosphatase (BAP), 5D4 epitope of keratan sulphate (KS), total glycosaminoglycans (GAG) and hyaluronan (HA) were measured. Results: The mean age of the horses was 4.1 years and the maximum durationof lameness was three months. Joints examined were midcarpal, antebrachiocarpal and metacarpophalangeal. The median concentration (semi-interquartilerange) of BAP was significantly higher in the clinically active joint thanin the contralateral joint, 21.75 (6.22) vs. 12.35 (4.07) units, while theother biomarkers measured were significantly lower in the clinically active joint than in the contralateral joint, i.e. KS 8.79 (1.96) mug/ml vs. 16.39 (5.65) mug/ml, KS:GAG ratio 0.19 (0.04) vs. 0.31 (0.10) and HA 741.6 (222) mug/ml vs. 1061.75 (325) mug/ml. BAP was positively (R=0.57), and KS (R=-0.57) and KS:GAG ratio (R=-0.49) were negatively correlated to the degreeof cartilage damage within the joint. Conclusion: The correlation between articular cartilage damage and synovial fluid BAP and KS imparts validity to their potential use as non-invasive diagnostic aids in equine osteoarthritis (OA). The positive correlation between BAP and cartilage damage suggests that there is a link between bone turnover and cartilage damage in OA. (C) 2001 OsteoArthritis Research Societyinternational.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 22:24:51