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Titolo:
Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model ofosteoarthritis
Autore:
Johnson, KA; Hulse, DA; Hart, RC; Kochevar, D; Chu, Q;
Indirizzi:
Ohio State Univ, Dept Vet Clin Sci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 et Clin Sci, Columbus, OH 43210 USA Texas A&M Univ, Dept Small Anim Med & Surg, College Stn, TX USA Texas A&M Univ College Stn TX USA l Anim Med & Surg, College Stn, TX USA Univ Wisconsin, Dept Surg Sci, Madison, WI USA Univ Wisconsin Madison WI USA Wisconsin, Dept Surg Sci, Madison, WI USA
Titolo Testata:
OSTEOARTHRITIS AND CARTILAGE
fascicolo: 1, volume: 9, anno: 2001,
pagine: 14 - 21
SICI:
1063-4584(200101)9:1<14:EOAOAM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEGENERATIVE JOINT DISEASE; ARTICULAR-CARTILAGE; KERATAN SULFATE; NATURAL-HISTORY; KNEE OSTEOARTHRITIS; POND-NUKI; GLYCOSAMINOGLYCANS; EFFICACY; AGGRECAN; TOLERABILITY;
Keywords:
chondroitin sulfate; glucosamine hydrochloride; manganese ascorbate; osteoarthritis; synovial fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, KA Ohio State Univ, Dept Vet Clin Sci, 601 Vernon L Tharp St, Columbus, OH 43210 USA Ohio State Univ 601 Vernon L Tharp St Columbus OH USA 43210 SA
Citazione:
K.A. Johnson et al., "Effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model ofosteoarthritis", OSTEO CART, 9(1), 2001, pp. 14-21

Abstract

Objective: To evaluate effects of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate (CS-G-M) on articular cartilage metabolism in dogs with cranial cruciate ligament (CCL) deficient and reconstructed knees, as reflected by concentrations of synovial fluid 383, 7D4 and total sulfated glycosaminoglycan (GAG). Methods: Sixteen adult dogs that underwent unilateral CCL transection wererandomized into four groups. Thereafter. group I (N=3) had a sham CCL reconstruction, group II (N=3) had CS-G-M and sham CCL reconstruction, group III (N=5) had CCL reconstruction, and group IV (N=5) had CS-G-M and CCL reconstruction. Synovial fluid collected at 0, 1, 3 and 5 months was examined byELISA for 383 and 7D4 epitope, and by DMMB assay for total GAG. Results: Synovial fluid from CCL transected knees of CS-G-M treated dogs contained significantly elevated concentrations of 383 (P=0.029), 7D4 (P=0.036) and 7D4/GAG (P=0.007) in comparison to controls, in a cross-sectional analysis at 3 months. Furthermore, 7D4 and 7D4/GAG concentrations remained significantly elevated (P=0.012) in CCL transected knees of CS-G-M treated dogs over the 5 month period. However. when epitope concentrations were expressed as a ratio of CCL-transected to contralateral non-operated knee, treatment effect of CS-G-M was no longer significant. Reconstruction of the CCLhad no significant effect on synovial fluid epitope. Conclusions: Administration of CS-G-M was associated with altered concentrations of 383 and 7D4 epitope in synovial fluid, suggesting that these compounds may act to modulate articular cartilage matrix metabolism in vivo. (C) 2001 OsteoArthritis Research Society International.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:54:04