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Titolo:
Coffee enhances the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinomas
Autore:
Saroja, M; Balasenthil, S; Ramachandran, CR; Nagini, S;
Indirizzi:
Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Fac Sci Annamalainagar Tamil Nadu India 608002 608002, Tamil Nadu, India Annamalai Univ, Rajah Muthiah Dent Coll & Hosp, Dept Oral Pathol, Annamalainagar 608002, Tamil Nadu, India Annamalai Univ Annamalainagar Tamil Nadu India 608002 , Tamil Nadu, India
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 2, volume: 37, anno: 2001,
pagine: 172 - 176
SICI:
1368-8375(200102)37:2<172:CETDO7>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTAGENIC ACTIVITY; CARCINOGENESIS; CANCER; NEEM; N-METHYL-N'-NITRO-N-NITROSOGUANIDINE; CAFFEINE; ASSAY; RATS;
Keywords:
oral cancer; chemoprevention; coffee; lipid peroxidation; antioxidants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Nagini, S Fac Sci, Dept Biochem, Annamalainagar 608002, Tamil Nadu, India Fac Sci Annamalainagar Tamil Nadu India 608002 amil Nadu, India
Citazione:
M. Saroja et al., "Coffee enhances the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch carcinomas", ORAL ONCOL, 37(2), 2001, pp. 172-176

Abstract

In this study, we examined the effect of roasted coffee extract on 7,12-dimethylbenz[a]anthracene (DMBA)-induced buccal pouch carcinogenesis in male Syrian hamsters using lipid peroxidation,, reduced glutathione (GSH) and glutathione peroxidase (GPx) activity as biomarkers of chemoprevention. Fortymale hamsters were divided into four groups of 10 animals. The right buccal pouches of the animals in Group 1 was painted with a 0.5% solution of DMBA in liquid paraffin three times a week. The animals in Group 2 painted with DMBA as in Group 1, received in addition 2 mi of 8% black coffee extract intragastrically three times a week on days alternate to DMBA application. Group 3 animals received coffee extract as in Group 2. Animals in Group 4 received neither DMBA nor coffee extract and served as control. The hamsterswere sacrificed after an experimental period of 14 weeks. Biochemical measurements were carried out on tumour and normal pouch tissues. Administration of roasted coffee extract had no preventive effect on DMBA-induced oral cancer as revealed by the higher mean tumour volume and tumour burden compared to animals painted with DMBA alone. Diminished lipid peroxidation in theoral tumour tissue was accompanied by a significant increase in the levelsof GSH and GPx. Conclusions: The results of the present study suggest thatcoffee exerts a tumour enhancing effects when administered during DMBA-induced hamster buccal pouch carcinogenesis. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 19:03:17