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Titolo:
Pretreatment apoptotic scores do not predict response to radiation therapyin oropharyngeal squamous cell carcinoma
Autore:
Tsuchiya, K; Shirato, H; Nishioka, T; Yamazaki, A; Hashimoto, S; Kagei, K; Oomori, K; Yasuda, M; Shindo, M; Miyasaka, K;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Radiol, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Dent, Dept Radiol, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan Hokkaido Univ, Sch Dent, Dept Pathol, Kita Ku, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 oro, Hokkaido 0608638, Japan
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 2, volume: 37, anno: 2001,
pagine: 159 - 163
SICI:
1368-8375(200102)37:2<159:PASDNP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR PROLIFERATION; GASTRIC CARCINOMAS; CERVICAL-CARCINOMA; RADIOTHERAPY; EXPRESSION; BLADDER; CANCER;
Keywords:
apoptosis; oropharyngeal carcinoma; squamous cell carcinoma; radiotherapy; mitosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Shirato, H Hokkaido Univ, Sch Med, Dept Radiol, Kita Ku, North 15 West 7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ North 15 West 7 Sapporo Hokkaido Japan 0608638 an
Citazione:
K. Tsuchiya et al., "Pretreatment apoptotic scores do not predict response to radiation therapyin oropharyngeal squamous cell carcinoma", ORAL ONCOL, 37(2), 2001, pp. 159-163

Abstract

The prognostic value of tumor apoptosis was studied in patients with oropharyngeal squamous cell carcinoma treated with radical radiotherapy. Forty-eight patients with oropharyngeal squamous cell carcinoma who received radical radiotherapy between 1990 and 1995 were enrolled in the study. The radiation treatment for all patients involved the administration of 65 Gy in 26 fractions over a 6.5-week period. The apoptotic index (AI; the apoptotic cell count per 1000 tumor cells) was distributed from 0 to 10 with a median at 2 and a mode of 1. There was a significant linear correlation between theAI and mitotic index (MI) (r = 0.393, 95% confidence interval: 0.129-0.605). The cause-specific 5-year survival for patients with AI greater than themedian was 46% and for the counterpart was 41%. There was no difference incause-specific survival between AI/MI greater than the median (50%) and AI/MI smaller than the median (36%). The number of patients was too small to draw definite conclusions, but the AI and the AI/MI before treatment were not shown to have a prognostic value for oropharyngeal squamous cell carcinoma in our study. The primary sites and treatment methods may influence the prognostic value of AI even for the same histological types. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/06/20 alle ore 01:48:06