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Titolo:
In vitro adsorption of Tc-99(m)-MIBI, Tc-99(m)-tetrofosmin, Tc-99(m)-furifosmin and (TcO4-)-Tc-99-O-m onto tubes
Autore:
Rodrigues, M; Chehne, F; Sinzinger, H;
Indirizzi:
Univ Hosp Vienna, Dept Nucl Med, A-1090 Vienna, Austria Univ Hosp Vienna Vienna Austria A-1090 Nucl Med, A-1090 Vienna, Austria
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 1, volume: 22, anno: 2001,
pagine: 105 - 110
SICI:
0143-3636(200101)22:1<105:IVAOTT>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
TC-99M;
Keywords:
adsorption of radioactivity; Tc-99(m)-MIBI; Tc-99(m)-tetrofosmin; Tc-99(m)-furifosmin; in-vitro cellular uptake;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
4
Recensione:
Indirizzi per estratti:
Indirizzo: Rodrigues, M Univ Hosp Vienna, Dept Nucl Med, Waehringer Guertel 18-20, A-1090 Vienna, Austria Univ Hosp Vienna Waehringer Guertel 18-20 Vienna Austria A-1090
Citazione:
M. Rodrigues et al., "In vitro adsorption of Tc-99(m)-MIBI, Tc-99(m)-tetrofosmin, Tc-99(m)-furifosmin and (TcO4-)-Tc-99-O-m onto tubes", NUCL MED C, 22(1), 2001, pp. 105-110

Abstract

Adsorption of radiopharmaceuticals onto disposable syringes has been reported to amount to levels of almost 50%. Data on adsorption of radiopharmaceuticals onto materials used for in vitro studies are extremely limited. We assessed the extent of adsorption of Tc-99(m) hexakis(2-methoxyisobutylisonitrile) (Tc-99(m)-MIBI), Tc-99(m)-tetrofosmin, Tc-99(m)-furifosmin and (TcO4-)-Tc-99-O-m onto tubes used for in vitro measurement of cellular uptake ofthese radiopharmaceuticals. The influence on adsorption of different incubation media, temperature and time of incubation was evaluated. Total (not corrected for adsorption) uptake was compared with corrected, net cellular uptake in SK-BR-3, MCF-7 and liposarcoma cell lines. Values of adsorption ranging from 0.94+/-0.13% to 7.07+/-0.46% were found. The extent of adsorption of all the radiopharmaceuticals varied with the type of incubation mediumand the incubation temperature. With Tc-99(m)-furifosmin, adsorption was dependent on the incubation time as well on the incubation temperature and some of the incubation media investigated. Our findings indicate that systematic in investigations to evaluate the adsorption of radiopharmaceuticals onto materials used during in vitro studies of cellular uptake should be considered a mandatory aspect of quality control. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 06:03:53