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Titolo:
Thallium gated SPECT: relation between immediate post-stress evolution of ejection fraction and severity of perfusion pattern
Autore:
Itti, E; Levy, M; Pouillart, F; Perez, T; Bellorini, M; Rosso, J; Meignan, M;
Indirizzi:
Univ Paris 12, Henri Mondor Hosp, Dept Nucl Med, Creteil, France Univ Paris 12 Creteil France ondor Hosp, Dept Nucl Med, Creteil, France
Titolo Testata:
NUCLEAR MEDICINE COMMUNICATIONS
fascicolo: 1, volume: 22, anno: 2001,
pagine: 57 - 64
SICI:
0143-3636(200101)22:1<57:TGSRBI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY DISEASE; RADIONUCLIDE ANGIOGRAPHY; MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; WALL-MOTION; EXERCISE; REST; TL-201; DYSFUNCTION;
Keywords:
201-thallium; gated SPECT; ejection fraction; perfusion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Itti, E CHU Henri Mondor, Nucl Med Serv, 51 Av Marechal de Lattre de Tassigny, F-94010 Creteil, France CHU Henri Mondor 51 Av Marechal de Lattre de Tassigny Creteil France F-94010
Citazione:
E. Itti et al., "Thallium gated SPECT: relation between immediate post-stress evolution of ejection fraction and severity of perfusion pattern", NUCL MED C, 22(1), 2001, pp. 57-64

Abstract

Background and aims A significant decrease of left ventricular ejection fraction (LVEF) at stress has been reported with Tc-99(m) gated single-photonemission computed tomography (gSPECT) in severe myocardial stunning up to 1 h after exercise. This study was designed to show whether Tl-201 gSPECT can measure LVEF evolution from rest to stress in routine examination and give additional information to perfusion interpretation since acquisition starts immediately after stress test. Methods Post-exercise and rest Tl-201 gSPECT were performed in 187 patients with suspected coronary artery disease. Myocardial perfusion was quantified by 20-segment analysis. Patients were divided into four groups accordingto their summed perfusion score, reversibility rate and electrocardiographic findings, i.e. in order of severity: I = normal perfusion, II = fixed defect owing to a myocardial infarction, III = full reversible ischaemia, andTV = partial reversible ischaemia. LVEF was calculated by Germane's automatic algorithm. Results Normal subjects (n=29) and infarcted patients (n=34) showed a significant LVEF increase between rest and stress, +7+/-9% and +5+/-7% respectively. In full reversible ischaemic patients (n=46), stress LVEF showed no increase (+1+/-8%) and this group was statistically different from both group I and group II. Furthermore, when ischaemia was partially reversible (n=31), LVEF decreased significantly (-3+/-8%), particularly when exercise tests were abnormal (-4+/-8%). Group IV was statistically different from groupsI and II. Conclusions Good agreement exists between the severity of ischaemic perfusion pattern and LVEF degradation at stress, which is consistent with previously published data using Tc-99(m) gSPECT. Additionally, the use of Tl-201 for immediate post-exercise imaging allows the observation of a physiological LVEF increase in normal and infarcted patients. ((C) 2001 Lippincott Williams & Wilkins).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:08:32